Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Vanessa I. Rasaiah"'
Autor:
Teruyuki Yanagisawa, Sean Devine, Toshihiro Takenaka, Koji Higuchi, Takeya Sato, Peter P. Liu, Chuwa Tei, Vanessa I. Rasaiah, Fayez Dawood, Manyin Chen, Bilal B. Ayach, Jeffrey A. Medin
Publikováno v:
Molecular Therapy. 17(2):262-268
Myocardial infarction (MI) and subsequent adverse remodeling cause heart failure. Previously we demonstrated a role for Kit ligand (KL) in improving cardiac function post-MI. KL has two major isoforms; KL-1 is secreted whereas KL-2 is predominantly m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbee6ea56d0318acdf1efa3e00bd7a9
Autor:
Chuyan Ying, Jonathan L. Bramson, Jagdeep S. Walia, Jason Foley, Daniel H. Fowler, Vanessa I. Rasaiah, Renee Head, Nicole Buxhoeveden, Miriam E. Mossoba, Jeffrey A. Medin
Publikováno v:
Molecular Therapy. 16(3):607-617
Gene therapy strategies may accelerate the development of prophylactic immunotherapy against cancer. We synthesized a lentiviral (LV) vector encoding a kinase-deficient form of erbB2 (erbB2tr) to transduce murine dendritic cells (DCs) efficiently. Mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce6ace612647421726762cb538733d3
Autor:
Makoto Yoshimitsu, Jeffrey A. Medin, Sheng-Ben Liang, Vanessa I. Rasaiah, Jianhui Cai, Daniel H. Fowler, Armando G. Poeppl
Publikováno v:
Molecular Therapy. 15:618-627
Hematopoietic cell transplantation can impact lysosomal storage disorders (LSDs) and will be enhanced by gene therapy. Transduced cells in LSDs often secrete the therapeutic hydrolase, which can be used by bystander cells. However, toxicity associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf6145f8cb84be2d71f3769f98fc9c8
https://doi.org/10.1038/sj.mt.6300075
https://doi.org/10.1038/sj.mt.6300075
Autor:
Vanessa I. Rasaiah, Christopher Siatskas, Roscoe O. Brady, Shobha Ramsubir, Makoto Yoshimitsu, Gary J. Murray, Takahiro Nonaka, Jeffrey A. Medin, Koji Higuchi, S-B Liang
Publikováno v:
Gene Therapy. 14:256-265
A deficiency in alpha-galactosidase A (alpha-gal A) activity causes Fabry disease. Virus-based delivery of genes can correct cells and establish a sustained supply of therapeutic proteins. Recombinant lentiviral vectors (LVs) show promise in this con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8f0900aad00b279e2e3c2ac9198149
https://doi.org/10.1038/sj.gt.3302839
https://doi.org/10.1038/sj.gt.3302839
Autor:
Jagdeep S. Walia, John Underwood, Gillian T. Sleep, Makoto Yoshimitsu, Vanessa I. Rasaiah, Armando G. Poeppl, Takeya Sato, Gary J. Murray, Lori J. West, Jeffrey A. Medin, Roscoe O. Brady, Kesheng Tao
Publikováno v:
Proceedings of the National Academy of Sciences. 101:16909-16914
Successful therapy for many inherited disorders could be improved if the intervention were initiated early. This is especially true for lysosomal storage disorders. Earlier intervention may allow metabolic correction to occur before lipid buildup has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d90fb67d4a397745a35f1a1c37877f2
https://doi.org/10.1073/pnas.0407572101
https://doi.org/10.1073/pnas.0407572101
Autor:
Makoto Yoshimitsu, Xiaoxin Guo, Chuwa Tei, Toshihiro Takenaka, Jeffrey A. Medin, Jennifer Yen, Koji Higuchi, Xin Fan, Vanessa I. Rasaiah
The protein transduction domain from human immunodeficiency virus (HIV) Tat allows proteins to penetrate the cell membrane. Enhanced cellular uptake of therapeutic proteins could benefit a number of disorders. This is especially true for lysosomal st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794222a93508faefb769c0d6a3e74c01
https://europepmc.org/articles/PMC2864812/
https://europepmc.org/articles/PMC2864812/
Autor:
Fayez Dawood, Manyin Chen, Vanessa I. Rasaiah, Makoto Yoshimitsu, Koji Higuchi, Peter Liu, Bilal B. Ayach, Jeffrey A. Medin
Publikováno v:
Circulation journal : official journal of the Japanese Circulation Society. 70(11)
Background Recombinant lentiviral vectors (LVs) offer the possibility of stable, long-term expression of transgenes even in non-dividing cells. In the present study this vector system was applied to a clinically relevant cardiovascular problem. Metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be57902fe7682c9a34be0c653bdf36b7
https://pubmed.ncbi.nlm.nih.gov/17062978
https://pubmed.ncbi.nlm.nih.gov/17062978
Publikováno v:
NDT Plus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2988cd9ff46ef3b94d3896caff07fa64
https://doi.org/10.1093/ndtplus/sfn009
https://doi.org/10.1093/ndtplus/sfn009
Autor:
Xin Fan, Jeffrey A. Medin, Toshihiro Takenaka, Makoto Yoshimitsu, Xiaoxin Guo, Vanessa I. Rasaiah, Koji Higuchi, Chuwa Tei
Publikováno v:
Journal of the American College of Cardiology. 55:A31.E296
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c862ee7cfb76400c87489303fbb1e8d4
https://doi.org/10.1016/s0735-1097(10)60297-5
https://doi.org/10.1016/s0735-1097(10)60297-5
Publikováno v:
Blood. 108:3696-3696
Anti-tumor immunotherapy is difficult to achieve in vivo in part due to naturally occurring peripheral tolerance. Our laboratory has developed a potent immunotherapy strategy that uses unusually low doses of dendritic cells (DCs) to break self-tolera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a12a60c518352095a940a6a78440564e
https://doi.org/10.1182/blood.v108.11.3696.3696
https://doi.org/10.1182/blood.v108.11.3696.3696