Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Vanessa Hui Qi, Koh"'
Autor:
Jieling Lim, Vanessa Hui Qi Koh, Sharol Su Lei Cho, Balamurugan Periaswamy, Dawn Poh Sum Choi, Maurizio Vacca, Paola Florez De Sessions, Pavol Kudela, Werner Lubitz, Giorgia Pastorin, Sylvie Alonso
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Tuberculosis (TB) pathogenesis is characterized by inadequate immune cell activation and delayed T cell response in the host. Recent immunotherapeutic efforts have been directed at stimulating innate immunity and enhancing interactions between antige
Externí odkaz:
https://doaj.org/article/a8c2fa4f44c849e784c7001d77def66b
Autor:
Sylvie Alonso, John Chan, Ekaterina N. Sviriaeva, Gerhard Grüber, Marvin J. Miller, Garrett C. Moraski, Vanessa Hui Qi Koh, Michael Berney, Jiayong Xu, Bei Shi Lee, Malathy Sony Subramanian Manimekalai, Dirk Schnappinger, Jared S. Mackenzie, Curtis A. Engelhart, Adrie J. C. Steyn, Kiel Hards, Kevin Pethe, Sherilyn Shi Min Chong, Erik J. Hasenoehrl, Nitin Pal Kalia, Gregory M. Cook
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 1, Pp n/a-n/a (2021)
EMBO Molecular Medicine, Vol 13, Iss 1, Pp n/a-n/a (2021)
The approval of bedaquiline has placed energy metabolism in the limelight as an attractive target space for tuberculosis antibiotic development. While bedaquiline inhibits the mycobacterial F1F0 ATP synthase, small molecules targeting other component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be61bb23a16a2d5337b93d0307834cf
https://doi.org/10.15252/emmm.202013207
https://doi.org/10.15252/emmm.202013207
Autor:
Vanessa Hui Qi Koh, Michael Berney, Dannah Rae Sajorda, Erik J. Hasenoehrl, Kevin Pethe, Nitin Pal Kalia, Michelle Lay Teng Ang, Kiel Hards, Nurlilah Binte Ab Rahman, Sylvie Alonso, Gerhard Grüber, Gregory M. Cook
Publikováno v:
Proceedings of the National Academy of Sciences. 114:7426-7431
The recent discovery of small molecules targeting the cytochrome bc 1 : aa 3 in Mycobacterium tuberculosis triggered interest in the terminal respiratory oxidases for antituberculosis drug development. The mycobacterial cytochrome bc 1 : aa 3 consist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac752f6214438bd30600bff155a481b1
https://doi.org/10.1073/pnas.1706139114
https://doi.org/10.1073/pnas.1706139114
Autor:
Michelle Lay Teng Ang, Garrett H. K. Teoh, Peter C. Dedon, Wenwei Lin, Sylvie Alonso, Yuan O. Zhu, Ahmad Naim Nazri Mohamed, Paola Florez de Sessions, Martin L. Hibberd, Vanessa Hui Qi Koh
Publikováno v:
Infection and Immunity. 84:2505-2523
Increasing experimental evidence supports the idea that Mycobacterium tuberculosis has evolved strategies to survive within lysosomes of activated macrophages. To further our knowledge of M. tuberculosis response to the hostile lysosomal environment,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c21eb3271604a29ecab1121a1be0e1
https://doi.org/10.1128/iai.00072-16
https://doi.org/10.1128/iai.00072-16
Autor:
Benedict Yan, Herbert Schwarz, Michelle Lay Teng Ang, Siti Zarina Zainul Rahim, Kevin Pethe, Julia María Martínez Gómez, Wenwei Lin, Vanessa Hui Qi Koh, Sylvie Alonso
Publikováno v:
Immunobiology. 219:78-86
The role of the CD137–CD137 ligand (CD137L) signaling pathway in T cell co-stimulation has been well established. Dysregulated CD137 or CD137L stimulation can lead to pathological conditions such as inflammatory diseases or cancer. However, the con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0462f138427969f304aa17cf69e4b380
https://doi.org/10.1016/j.imbio.2013.08.009
https://doi.org/10.1016/j.imbio.2013.08.009
Autor:
Vanessa Hui Qi, Koh, See Liang, Ng, Michelle Lay Teng, Ang, Wenwei, Lin, Christiane, Ruedl, Sylvie, Alonso
Publikováno v:
Tuberculosis (Edinburgh, Scotland). 102
Despite international control programmes, the global burden of tuberculosis remains enormous. Efforts to discover novel drugs have largely focused on targeting the bacterium directly. Alternatively, manipulating the host immune response may represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbabd7ac3a52c2f9237b9b9b49dce10a
https://pubmed.ncbi.nlm.nih.gov/28061951
https://pubmed.ncbi.nlm.nih.gov/28061951
Urease activity represents an alternative pathway for Mycobacterium tuberculosis nitrogen metabolism
Autor:
Mai Ping Tan, Emily Ang, Vanessa Hui Qi Koh, Julia María Martínez Gómez, Kevin Pethe, Wenwei Lin, Sylvie Alonso, Michelle Lay Teng Ang, Siti Zarina Zainul Rahim, Vanessa Mathys
Publikováno v:
Infection and immunity. 80(8)
Urease represents a critical virulence factor for some bacterial species through its alkalizing effect, which helps neutralize the acidic microenvironment of the pathogen. In addition, urease serves as a nitrogen source provider for bacterial growth.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39600306011b53247d2ef00d28645017
https://pubmed.ncbi.nlm.nih.gov/22645285
https://pubmed.ncbi.nlm.nih.gov/22645285
Autor:
Vanessa Hui Qi Koh, Julia María Martínez Gómez, Sylvie Alonso, Wenwei Lin, Jan Madacki, Anne K. Bendt, Siti Zarina Zainul Rahim, Petronela Dianišková, Markus R. Wenk, Jana Korduláková, Guanghou Shui, Kevin Pethe, Michelle Lay Teng Ang, Katarína Mikušová, Sukumar Sudarkodi
Publikováno v:
Infection and Immunity. 83:846-846
Volume 82, no. 5, p. [1850–1859][1], 2014. Page 1850: The article byline should read as given above. [1]: /lookup/doi/10.1128/IAI.01332-13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::512234cc01a5ad8a7633600b53976f20
https://doi.org/10.1128/iai.02884-14
https://doi.org/10.1128/iai.02884-14