Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Vanessa Gwenin"'
Publikováno v:
MicrobiologyOpen, Vol 9, Iss 10, Pp n/a-n/a (2020)
Abstract Directed enzyme prodrug therapy (DEPT) is a cancer chemotherapy strategy in which bacterial enzymes are delivered to a cancer site before prodrug administration, resulting in prodrug activation at the cancer site and more localized treatment
Externí odkaz:
https://doaj.org/article/c861a008e39e4900ad9cd58acd6875f8
Autor:
Patrick Ball, Robert Hobbs, Simon Anderson, Emma Thompson, Vanessa Gwenin, Christopher Von Ruhland, Christopher Gwenin
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 517 (2021)
The bacterial nitroreductase NfnB has been the focus of a great deal of research for its use in directed enzyme prodrug therapy in combination with the nitroreductase prodrug CB1954 with this combination of enzyme and prodrug even entering clinical t
Externí odkaz:
https://doaj.org/article/24a62a4fe0ae4f908ea6f8377f2c0041
Autor:
Patrick Ball, Emma Thompson, Simon Anderson, Vanessa Gwenin, Amir Ashoorzadeh, Jeff Smaill, Chris Gwenin
Publikováno v:
Bioscience Reports. 43
Directed enzyme prodrug therapy is a highly promising anti-cancer strategy. However, the current technology is limited by inefficient prodrug activation and the dose-limiting toxicity associated with the prodrugs being tested; to overcome these limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bae18597bb6f079c8f4a5bfc53688f87
https://doi.org/10.1042/bsr20230627
https://doi.org/10.1042/bsr20230627