Enzymatic and Chemoenzymatic Three-Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines

Autor: Vanessa Erdmann, Jianxiong Zhao, Wolfgang Kroutil, Robert C. Simon, Dörte Rother, John M. Ward, Benjamin R. Lichman, Helen C. Hailes

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie / International edition 56(41), 12503-12507 (2017). doi:10.1002/anie.201705855

Chemoenzymatic and enzymatic cascade reactions enable the synthesis of complex stereocomplementary 1,3,4‐trisubstituted tetrahydroisoquinolines (THIQs) with three chiral centers in a step‐efficient and selective manner without intermediate purifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8069230ad85025859ce007e7bc266272
https://eprints.whiterose.ac.uk/139641/1/Erdmann_et_al_2017_Angewandte_Chemie_International_Edition.pdf

Enantioselective, continuous (R)- and (S)-2-butanol synthesis: achieving high space-time yields with recombinant E. coli cells in a micro-aqueous, solvent-free reaction system

Autor: Andre Jakoblinnert, Vanessa Erdmann, Ursula Mackfeld, Dörte Rother

Publikováno v: Journal of biotechnology. 191

The stereoselective production of (R)- or (S)-2-butanol is highly challenging. A potent synthesis strategy is the biocatalytic asymmetric reduction of 2-butanone applying alcohol dehydrogenases. However, due to a time-dependent racemisation process,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198079423697eef3985c10b183f3168a
https://pubmed.ncbi.nlm.nih.gov/25036751