Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Vanessa Drosdek"'
Autor:
Viktor Glaser, Christian Flugel, Jonas Kath, Weijie Du, Vanessa Drosdek, Clemens Franke, Maik Stein, Axel Pruß, Michael Schmueck-Henneresse, Hans-Dieter Volk, Petra Reinke, Dimitrios L. Wagner
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Background Multiple genetic modifications may be required to develop potent off-the-shelf chimeric antigen receptor (CAR) T cell therapies. Conventional CRISPR-Cas nucleases install sequence-specific DNA double-strand breaks (DSBs), enabling
Externí odkaz:
https://doaj.org/article/f8d60eb28eca4425aa804f59ead59de2
Autor:
Jonas Kath, Weijie Du, Stefania Martini, Magdi Elsallab, Clemens Franke, Laura Marie Hartmann, Vanessa Drosdek, Viktor Glaser, Maik Stein, Michael Schmueck-Henneresse, Petra Reinke, Hans-Dieter Volk, Mohamed Abou-el-Enein, Dimitrios Laurin Wagner
Publikováno v:
Blood Advances.
Graft-versus-host disease (GvHD) is a major risk upon administration of allogeneic Chimeric Antigen Receptor (CAR) redirected T cells to HLA-unmatched patients. Gene editing can be used to disrupt potentially alloreactive T cell receptors (TCRs) in C