Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes

Autor: Rajashree Mishra, Alessandra Chesi, Diana L. Cousminer, Mohammad I. Hawa, Jonathan P. Bradfield, Kenyaita M. Hodge, Vanessa C. Guy, Hakon Hakonarson, Bone Mineral Density in Childhood Study, Didac Mauricio, Nanette C. Schloot, Knud B. Yderstræde, Benjamin F. Voight, Stanley Schwartz, Bernhard O. Boehm, Richard David Leslie, Struan F. A. Grant

Publikováno v: BMC Medicine, Vol 15, Iss 1, Pp 1-10 (2017)

Abstract Background In adulthood, autoimmune diabetes can present as non-insulin-requiring diabetes, termed as ‘latent autoimmune diabetes in adults’ (LADA). In this study, we investigated established type 1 diabetes (T1D) and type 2 diabetes (T2

Externí odkaz: https://doaj.org/article/08c23508763e430eba29598b446d78de

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

Autor: Daniel R. Witte, Vanessa C. Guy, Hakon Hakonarson, Ivan Brandslund, Henrik Vestergaard, Rajashree Mishra, Olle Melander, Torben Hansen, Benjamin F. Voight, Annemari Käräjämäki, Fernando Ovalle, Asa Davis, R. David Leslie, Kenyaita M. Hodge, Stanley Schwartz, Lars G. Fritsche, Emma Ahlqvist, David J. Brillon, Didac Mauricio, Mette K. Andersen, Stephen Varvel, Kaixin Zhou, Bjørn Olav Åsvold, Mikael Åkerlund, Niels Grarup, Leif Groop, Philippe Froguel, Diana L. Cousminer, Alessandra Chesi, Adrian Vella, Jonathan P. Bradfield, Tiinamaija Tuomi, Ronald I. Harris, Elin Pettersen Sørgjerd, James Snyder, Carla J. Greenbaum, M. I. Hawa, Michael R. Rickels, Kurt Højlund, Allan Linneberg, Bernhard O. Boehm, Ewan R. Pearson, Oluf Pedersen, Richard E. Pratley, Nanette C. Schloot, Kamlesh Khunti, Henning Beck-Nielsen, Cecilia E. Kim, Valdemar Grill, Mette Wod, John T. Lonsdale, Knud Bonnet Yderstræde, Struan F.A. Grant

Publikováno v: Groop, L C, Leslie, R D, Grant, S F A & Bone Mineral Density in Childhood Study 2018, ' First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes ', Diabetes Care, vol. 41, no. 11, pp. 2396-2403 . https://doi.org/10.2337/dc18-1032
Diabetes Care
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Cousminer, D L, Ahlqvist, E, Mishra, R, Andersen, M K, Chesi, A, Hawa, M I, Davis, A, Hodge, K M, Bradfield, J P, Zhou, K, Guy, V C, Akerlund, M, Wod, M, Fritsche, L G, Vestergaard, H, Snyder, J, Højlund, K, Linneberg, A, Käräjämäki, A, Brandslund, I, Kim, C E, Witte, D, Sørgjerd, E P, Brillon, D J, Pedersen, O, Beck-Nielsen, H, Grarup, N, Pratley, R E, Rickels, M R, Vella, A, Ovalle, F, Melander, O, Harris, R I, Varvel, S, Grill, V E R, Bone Mineral Density in Childhood Study, Hakonarson, H, Froguel, P, Lonsdale, J T, Mauricio, D, Schloot, N C, Khunti, K, Greenbaum, C J, Asvold, B O, Yderstræde, K B, Pearson, E R, Schwartz, S, Voight, B F, Hansen, T, Tuomi, T & Boehm, B O 2018, ' First genome-wide association study of latent autoimmune diabetes in adults reveals novel insights linking immune and metabolic diabetes ', Diabetes Care, vol. 41, no. 11, pp. 2396-2403 . https://doi.org/10.2337/dc18-1032

OBJECTIVE Latent autoimmune diabetes in adults (LADA) shares clinical features with both type 1 and type 2 diabetes; however, there is ongoing debate regarding the precise definition of LADA. Understanding its genetic basis is one potential strategy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a67a805e834eac5811cf022a2340e8e
http://hdl.handle.net/10138/306614

Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults

Autor: Vanessa C. Guy, Kevin J. Basile, Stanley Schwartz, Struan F.A. Grant

Publikováno v: Current diabetes reports. 14(11)

Despite the notion that there is a degree of commonality to the biological etiology of type 1 diabetes (T1D) and type 2 diabetes (T2D), the lack of overlap in the genetic factors underpinning each of them suggests very distinct mechanisms. A disorder

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2f23e17f4b09697ddf58b01bd61f1c
https://pubmed.ncbi.nlm.nih.gov/25189437

Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in mice

Autor: Curt R. Freed, Wenbo Zhou, Vanessa C. Guy, Young Mook Lee

Publikováno v: Stem cells (Dayton, Ohio). 27(12)

Parkinson's disease (PD) is characterized by the selective loss of midbrain dopamine neurons. Neural transplantation with fetal dopamine neurons can be an effective therapy for patients with PD, but recovery of human fetal cells is difficult. Scarcit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6b6d36ae55d1d0a7e51175d72e9471
https://pubmed.ncbi.nlm.nih.gov/19750538