Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Vanessa C. Gaerig"'
Publikováno v:
Molecules, Vol 18, Iss 12, Pp 15019-15034 (2013)
ADAM-15, with known zymogen, secretase, and disintegrin activities, is a catalytically active member of the ADAM family normally expressed in early embryonic development and aberrantly expressed in various cancers, including breast, prostate and lung
Externí odkaz:
https://doaj.org/article/ae5ea5ae43e14ad69b5d7d727df54ede
Publikováno v:
Nucleic Acids Research
The MYC proto-oncogene is upregulated, often at the transcriptional level, in ∼80% of all cancers. MYC's promoter is governed by a higher order G-quadruplex (G4) structure in the NHE III1 region. Under a variety of conditions, multiple isoforms hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b37ee735430ff53e21ae1efa578f07e
http://europepmc.org/articles/PMC5159522
http://europepmc.org/articles/PMC5159522
Autor:
Vanessa C. Gaerig, Vijay Gokhale, Zhongbo Yu, Hanbin Mao, Laurence H. Hurley, Yuan Zhao, Hyun-Jin Kang, Yunxi Cui
Publikováno v:
Journal of the American Chemical Society. 134:5157-5164
The discovery of G-quadruplexes and other DNA secondary elements has increased the structural diversity of DNA well beyond the ubiquitous double helix. However, it remains to be determined whether tertiary interactions can take place in a DNA complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9a7307963bc650a38448271025537e
https://doi.org/10.1021/ja210399h
https://doi.org/10.1021/ja210399h
Publikováno v:
Biochimica et biophysica acta. 1859(2)
kRAS is one of the most prevalent oncogenic aberrations. It is either upregulated or mutationally activated in a multitude of cancers, including pancreatic, lung, and colon cancers. While a significant effort has been made to develop drugs that targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca062bd79773b2f9ead37c0f986708ce
https://pubmed.ncbi.nlm.nih.gov/26597160
https://pubmed.ncbi.nlm.nih.gov/26597160
Publikováno v:
Molecules
Volume 18
Issue 12
Pages 15019-15034
Molecules, Vol 18, Iss 12, Pp 15019-15034 (2013)
Volume 18
Issue 12
Pages 15019-15034
Molecules, Vol 18, Iss 12, Pp 15019-15034 (2013)
ADAM-15, with known zymogen, secretase, and disintegrin activities, is a catalytically active member of the ADAM family normally expressed in early embryonic development and aberrantly expressed in various cancers, including breast, prostate and lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78b1e298f18f804bef56f98207d33ab
https://pubmed.ncbi.nlm.nih.gov/24317528
https://pubmed.ncbi.nlm.nih.gov/24317528
Publikováno v:
Cancer Research. 72:1829-1829
kRAS is one of, if not the, most prevalent oncogenic aberrations identified to date. It is either upregulated or mutationally activated in a multitude of cancers, including close to 100% of pancreatic adenocarcinomas. Pancreatic cancer carries the hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c52f8f2612562c8782944cc84567f99
https://doi.org/10.1158/1538-7445.am2012-1829
https://doi.org/10.1158/1538-7445.am2012-1829
Publikováno v:
Cancer Research. 72:4757-4757
The c-MYC oncogene is upregulated in almost 80% of cancers, and in some cases is the causative oncogenic factor. It is regulated at the transcriptional level with up to 90% initiating at the P1 and P2 promoters. The NHE III1 element regulates this re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd6b83775ca26985a55516b933efb36e
https://doi.org/10.1158/1538-7445.am2012-4757
https://doi.org/10.1158/1538-7445.am2012-4757
Publikováno v:
Cancer Research. 70:1386-1386
The anti-angiogenic approach is traditionally considered for solid malignancies, but increasing evidence has also highlighted its involvement in the progression of hematological oncologies. Angiogenesis, including expression of key proteins, is aberr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b4f0ac1ad829211f9feafe412422ce8
https://doi.org/10.1158/1538-7445.am10-1386
https://doi.org/10.1158/1538-7445.am10-1386
Publikováno v:
Cancer Research. 70:3681-3681
Breast cancer is the most common form of cancer in women, whose lethality is only surpassed by lung cancer. Through the last quarter-century there have been significant advances in detection and treatment options, such as Herceptin for HER2/neu posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81f0911ad3fe1580c7fce8e9511ab3e4
https://doi.org/10.1158/1538-7445.am10-3681
https://doi.org/10.1158/1538-7445.am10-3681