GOLPH3 Regulates EGFR in T98G Glioblastoma Cells by Modulating Its Glycosylation and Ubiquitylation

Autor: Cecilia Arriagada, Viviana A. Cavieres, Charlotte Luchsinger, Alexis E. González, Vanessa C. Muñoz, Jorge Cancino, Patricia V. Burgos, Gonzalo A. Mardones

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 22, p 8880 (2020)

Protein trafficking is altered when normal cells acquire a tumor phenotype. A key subcellular compartment in regulating protein trafficking is the Golgi apparatus, but its role in carcinogenesis is still not well defined. Golgi phosphoprotein 3 (GOLP

Externí odkaz: https://doaj.org/article/1aee551729d3488d8bdd9a26ef1353ab

Turnover of C99 is controlled by a crosstalk between ERAD and ubiquitin-independent lysosomal degradation in human neuroglioma cells.

Autor: Hianara A Bustamante, Andrés Rivera-Dictter, Viviana A Cavieres, Vanessa C Muñoz, Alexis González, Yimo Lin, Gonzalo A Mardones, Patricia V Burgos

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e83096 (2013)

Alzheimer's disease (AD) is characterized by the buildup of amyloid-β peptides (Aβ) aggregates derived from proteolytic processing of the β-amyloid precursor protein (APP). Amyloidogenic cleavage of APP by β-secretase/BACE1 generates the C-termin

Externí odkaz: https://doaj.org/article/85bed3ae004d4287a6f9f193c954a431

Autophagosomes cooperate in the degradation of intracellular C‐terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway

Autor: Alexis E González, Yunan C Januário, Gonzalo A. Mardones, Vanessa C. Muñoz, Viviana A Cavieres, Patricia V. Burgos, Hianara A. Bustamante, Claudio Hetz, Luis L. P. daSilva, Ibeth González, Alejandro Rojas-Fernandez, Víctor-Hugo Cornejo, Ronald T. Hay

Publikováno v: The Faseb Journal
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Brain regions affected by Alzheimer disease (AD) display well-recognized early neuropathologic features in the endolysosomal and autophagy systems of neurons, including enlargement of endosomal compartments, progressive accumulation of autophagic vac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8143301e35d6e40d10818c78944c32af
https://doi.org/10.1096/fj.201600713r

Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein

Autor: Alexis E, González, Vanessa C, Muñoz, Viviana A, Cavieres, Hianara A, Bustamante, Víctor-Hugo, Cornejo, Yunan C, Januário, Ibeth, González, Claudio, Hetz, Luis L, daSilva, Alejandro, Rojas-Fernández, Ronald T, Hay, Gonzalo A, Mardones, Patricia V, Burgos

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31(6)

Brain regions affected by Alzheimer disease (AD) display well-recognized early neuropathologic features in the endolysosomal and autophagy systems of neurons, including enlargement of endosomal compartments, progressive accumulation of autophagic vac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f01aceaf5b864a50075d95e26b63164
https://pubmed.ncbi.nlm.nih.gov/28254759

Turnover of c99 is controlled by a crosstalk between erad and ubiquitin-independent lysosomal degradation in human neuroglioma cells

Autor: Yimo Lin, Alexis E González, Viviana A Cavieres, Hianara A. Bustamante, Gonzalo A. Mardones, Vanessa C. Muñoz, Andrés Rivera-Dictter, Patricia V. Burgos

Publikováno v: PLOS ONE
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e83096 (2013)

Alzheimer's disease (AD) is characterized by the buildup of amyloid-β peptides (Aβ) aggregates derived from proteolytic processing of the β-amyloid precursor protein (APP). Amyloidogenic cleavage of APP by β-secretase/BACE1 generates the C-termin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa0c344462f7fda5ccf23c26ad4ba55