Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Vanessa Baier"'
Autor:
Vanessa Baier, Alicia Paini, Stephan Schaller, Colin G. Scanes, Audrey J. Bone, Markus Ebeling, Thomas G. Preuss, Johannes Witt, David Heckmann
Publikováno v:
Environment International, Vol 169, Iss , Pp 107547- (2022)
Physiologically-based kinetic (PBK) models are effective tools for designing toxicological studies and conducting extrapolations to inform hazard characterization in risk assessment by filling data gaps and defining safe levels of chemicals. In the p
Externí odkaz:
https://doaj.org/article/538906f5c3854aa58c32c8940c07db7d
Autor:
Colin G. Scanes, Johannes Witt, Markus Ebeling, Stephan Schaller, Vanessa Baier, Audrey J. Bone, Thomas G. Preuss, David Heckmann
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Physiologically based kinetic (PBK) models facilitate chemical risk assessment by predicting in vivo exposure while reducing the need for animal testing. PBK models for mammals have seen significant progress, which has yet to be achieved for avian sy
Externí odkaz:
https://doaj.org/article/09094be1b329470ca8bc8aaf1821c6a9
Autor:
Colin G. Scanes, Johannes Witt, Markus Ebeling, Stephan Schaller, Vanessa Baier, Audrey J. Bone, Thomas G. Preuss, David Heckmann
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Physiologically based kinetic (PBK) models are a promising tool for xenobiotic environmental risk assessment that could reduce animal testing by predicting in vivo exposure. PBK models for birds could further our understanding of species-specific sen
Externí odkaz:
https://doaj.org/article/bdb0a64ecaea48b2bd5331d5090c675b
Autor:
Vanessa Baier, Henrik Cordes, Christoph Thiel, José V. Castell, Ulf P. Neumann, Lars M. Blank, Lars Kuepfer
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Drug-induced liver injury (DILI) is a matter of concern in the course of drug development and patient safety, often leading to discontinuation of drug-development programs or early withdrawal of drugs from market. Hepatocellular toxicity or impairmen
Externí odkaz:
https://doaj.org/article/e570eacc0c9a436fa107a7f433af15bd
Autor:
Ramona Nudischer, Adrian Roth, Vanessa Baier, Lars M. Blank, José V. Castell, Jens M. Kelm, Annika R. P. Schneider, Florian Caiment, Hans Gmuender, Christoph Thiel, Lars Kuepfer, Wolfgang Moritz, Yannick Schrooders, Henrik Cordes, Jos C. S. Kleinjans, Christian Trautwein, Timo Wittenberger, Olivia Clayton, Ulf P. Neumann
Publikováno v:
Clinical pharmacology & therapeutics : CPT 110(5), 1293-1301 (2021). doi:10.1002/cpt.2406
Clinical Pharmacology & Therapeutics, 110(5), 1293-1301. Wiley
CLINICAL PHARMACOLOGY & THERAPEUTICS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Clinical Pharmacology & Therapeutics, 110(5), 1293-1301. Wiley
CLINICAL PHARMACOLOGY & THERAPEUTICS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
We present a generic workflow combining physiology-based computational modeling and in vitro data to assess the clinical cholestatic risk of different drugs systematically. Changes in expression levels of genes involved in the enterohepatic circulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bb897e70f87a57b55a2225fb471753
https://doi.org/10.1002/cpt.2406
https://doi.org/10.1002/cpt.2406
Autor:
Christoph Thiel, Henrik Cordes, Lorenzo Fabbri, Hélène Eloise Aschmann, Vanessa Baier, Ines Smit, Francis Atkinson, Lars Mathias Blank, Lars Kuepfer
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 2, p e1005280 (2017)
Drug-induced toxicity is a significant problem in clinical care. A key problem here is a general understanding of the molecular mechanisms accompanying the transition from desired drug effects to adverse events following administration of either ther
Externí odkaz:
https://doaj.org/article/f4f152c4bb14447cae0bb34606d7c79f
Autor:
Annika R. P. Schneider, Carolin V. Schneider, Kai Markus Schneider, Vanessa Baier, Steffen Schaper, Christian Diedrich, Katrin Coboeken, Hannah Mayer, Wenyi Gu, Jonel Trebicka, Lars M. Blank, Rolf Burghaus, Joerg Lippert, Daniel J. Rader, Christoph A. Thaiss, Jan‐Frederik Schlender, Christian Trautwein, Lars Kuepfer
Publikováno v:
Liver international 42(3), 640-650 (2022). doi:10.1111/liv.15161
Liver international 42(3), 640-650 (2022). doi:10.1111/liv.15161
Published by Wiley-Blackwell, Oxford
Published by Wiley-Blackwell, Oxford
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a74bf26157c369ef3b5f0fdc1ea29f
https://pubmed.ncbi.nlm.nih.gov/35294103
https://pubmed.ncbi.nlm.nih.gov/35294103
Autor:
Witold Wolski, Irina Agarkova, Hans Gmuender, Stefano Gotta, Ugis Sarkans, Ralf Herwig, Adrian Roth, Johannes Schuchhardt, Henrik Cordes, Patrick Guye, Bernd Timmermann, Steven A. Niederer, Jos C. S. Kleinjans, Marcha Verheijen, Jasmine Minguet, Sally J. Deeb, Carla Pluess, Vanessa Baier, Matthias Lienhard, Ivo Bachmann, Jort J. Merken, Alexandra Zerck, Stefan Boerno, Ramona Nudischer, Anne Hersey, Christoph Thiel, Francis Atkinson, Olivia Clayton, Laura Kunz, Lars Kuepfer, Fiona M. I. Hunter, Christopher F. Bauer, Stephane Heymans, Yannick Schrooders, Gal Barel, Nathalie Selevsek, Alex Lewalle, Ralph Schlapbach, Nicolas Bosc, Florian Caiment, Timo Wittenberger, Ines Smit, Bernardo Lino de Oliveira
Publikováno v:
Communications Biology
Communications Biology, 3(1):573. Nature Publishing Group
Communications biology 3, 573 (2020). doi:10.1038/s42003-020-01302-8
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Communications Biology, 3(1):573. Nature Publishing Group
Communications biology 3, 573 (2020). doi:10.1038/s42003-020-01302-8
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Uncovering cellular responses from heterogeneous genomic data is crucial for molecular medicine in particular for drug safety. This can be realized by integrating the molecular activities in networks of interacting proteins. As proof-of-concept we ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813f559344f81693cd246f68ab1aa3b4
http://europepmc.org/articles/PMC7567116
http://europepmc.org/articles/PMC7567116
Publikováno v:
Journal de Thérapie Comportementale et Cognitive. 28:152-159
Resume Le refus scolaire est une problematique courante qui est susceptible de concerner tous les eleves et qui peut avoir des consequences deleteres sur la sante mentale a moyen et long terme (King et al., 2000). En Suisse, environ 5 % des eleves ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad676924daeb9923b3c8c148fbfa9d61
https://doi.org/10.1016/j.jtcc.2018.06.008
https://doi.org/10.1016/j.jtcc.2018.06.008
Publikováno v:
npj Systems Biology and Applications, Vol 4, Iss 1, Pp 1-11 (2018)
NPJ Systems Biology and Applications
npj Systems biology and applications 4(1), 10 (2018). doi:10.1038/s41540-018-0048-1
NPJ Systems Biology and Applications
npj Systems biology and applications 4(1), 10 (2018). doi:10.1038/s41540-018-0048-1
Drug-induced perturbations of the endogenous metabolic network are a potential root cause of cellular toxicity. A mechanistic understanding of such unwanted side effects during drug therapy is therefore vital for patient safety. The comprehensive ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eff14c905587546f5bed7fd68e6942b
http://link.springer.com/article/10.1038/s41540-018-0048-1
http://link.springer.com/article/10.1038/s41540-018-0048-1