Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Vanessa A. Leone"'
Autor:
Sungjoon Cho, Xiaotong Yang, Kyoung-Jae Won, Vanessa A. Leone, Eugene B. Chang, Grace Guzman, Yeonju Ko, Ok-Nam Bae, Hyunwoo Lee, Hyunyoung Jeong
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTThe gut microbiota affects hepatic drug metabolism. However, gut microbial factors modulating hepatic drug metabolism are largely unknown. In this study, using a mouse model of acetaminophen (APAP)-induced hepatotoxicity, we identified a gut
Externí odkaz:
https://doaj.org/article/44a847d2845a476a9d7eee8f022f66fe
Autor:
Katya Frazier, Sumeed Manzoor, Katherine Carroll, Orlando DeLeon, Sawako Miyoshi, Jun Miyoshi, Marissa St. George, Alan Tan, Evan A. Chrisler, Mariko Izumo, Joseph S. Takahashi, Mrinalini C. Rao, Vanessa A. Leone, Eugene B. Chang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Circadian rhythms govern glucose homeostasis, and their dysregulation leads to complex metabolic diseases. Gut microbes exhibit diurnal rhythms that influence host circadian networks and metabolic processes, yet underlying mechanisms remain elusive.
Externí odkaz:
https://doaj.org/article/2b3926a172264fbfb7638c31f72999c6
Autor:
Young me Yoon, Cara L. Hrusch, Na Fei, Gabriel M. Barrón, Kathleen A. M. Mills, Maile K. Hollinger, Tania E. Velez, Vanessa A. Leone, Eugene B. Chang, Anne I. Sperling
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Airway instillation of bleomycin (BLM) in mice is a widely used, yet challenging, model for acute lung injury (ALI) with high variability in treatment scheme and animal outcomes among investigators. Whether the gut microbiota play
Externí odkaz:
https://doaj.org/article/68130328ac994fabae9d0657fd22b946
Autor:
Vanessa A. Leone, Kenneth G. Onishi, Megan Kennedy, Jonathan P. Riggle, Joseph F. Pierre, Andrew C. Maneval, Melanie N. Spedale, Betty R. Theriault, Eugene B. Chang, Brian J. Prendergast
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Trillions of microbial oscillators reside throughout the mammalian body, yet their contributions toward fundamental features of host circadian rhythms (CRs) have not been characterized. Here, we demonstrate that the microbiome contributes to
Externí odkaz:
https://doaj.org/article/76a48434c7954ca593cab7492814ca79
Autor:
Edmund B. Chen, Katherine E. Shapiro, Kelly Wun, Thomas Kuntz, Betty R. Theriault, Michael J. Nooromid, Vanessa A. Leone, Katharine G. Harris, Qun Jiang, Melanie Spedale, Liqun Xiong, Jack A. Gilbert, Eugene B. Chang, Karen J. Ho
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 5 (2020)
Background The potential role of the gut microbiome in cardiovascular diseases is increasingly evident. Arterial restenosis attributable to neointimal hyperplasia after cardiovascular procedures such as balloon angioplasty, stenting, and bypass surge
Externí odkaz:
https://doaj.org/article/56f732a5edd944d1a32d1c0f09ac2abb
Publikováno v:
Biology, Vol 9, Iss 12, p 417 (2020)
Circadian rhythms are essential for nearly all life forms, mediated by a core molecular gene network that drives downstream molecular processes involved in immune function and metabolic regulation. These biological rhythms serve as the body’s metro
Externí odkaz:
https://doaj.org/article/cf17eca2462643f79ed0f72b35ef43a8
Autor:
Na Fei, Sawako Miyoshi, Jake B. Hermanson, Jun Miyoshi, Bingqing Xie, Orlando DeLeon, Maximilian Hawkins, William Charlton, Mark D’Souza, John Hart, Dinanath Sulakhe, Kristina B. Martinez-Guryn, Eugene B. Chang, Michael R. Charlton, Vanessa A. Leone
Publikováno v:
bioRxiv
SummaryNonalcoholic fatty liver disease (NAFLD) is multifactorial in nature, affecting over a billion people worldwide. The gut microbiome has emerged as an associative factor in NAFLD, yet mechanistic contributions are unclear. Here, we show fast fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3301c3aa0186b869c8a7828b6fb8dc
https://europepmc.org/articles/PMC9882021/
https://europepmc.org/articles/PMC9882021/
Autor:
Celeste Allaband, Amulya Lingaraju, Stephany Flores Ramos, Tanya Kumar, Haniyeh Javaheri, Maria D. Tiu, Ana Carolina Dantas Machado, Roland A. Richter, Emmanuel Elijah, Gabriel G. Haddad, Vanessa A. Leone, Pieter C. Dorrestein, Rob Knight, Amir Zarrinpar
Although many aspects of microbiome studies have been standardized to improve experimental replicability, none account for how the daily diurnal fluctuations in the gut lumen cause dynamic changes in 16S amplicon sequencing. Here we show that sample
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::776057daa0f51246962486b7008f8ba7
https://doi.org/10.1101/2022.10.26.513817
https://doi.org/10.1101/2022.10.26.513817
Autor:
Samar A, Tolba, Vanessa A, Leone
Publikováno v:
Nature reviews. Endocrinology. 18(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c353995345842749daacc616af1de730
https://pubmed.ncbi.nlm.nih.gov/35793637
https://pubmed.ncbi.nlm.nih.gov/35793637
Autor:
Katya Frazier, Sumeed Manzoor, Katherine Carroll, Orlando DeLeon, Sawako Miyoshi, Jun Miyoshi, Marissa St George, Alan Tan, Mariko Izumo, Joseph S. Takahashi, Mrinalini C. Rao, Vanessa A. Leone, Eugene B. Chang
SummaryCircadian rhythms govern glucose homeostasis, and their dysregulation leads to complex metabolic diseases. Gut microbes also exhibit diurnal rhythms that influence host circadian networks and metabolic processes, yet underlying mechanisms rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb87b302e83790a8152c3cca166153be
https://doi.org/10.1101/2022.05.24.491361
https://doi.org/10.1101/2022.05.24.491361