Diverse effects of interferon alpha on the establishment and reversal of HIV latency.

Autor: Renée M Van der Sluis, Jennifer M Zerbato, Jake W Rhodes, Rachel D Pascoe, Ajantha Solomon, Nitasha A Kumar, Ashanti I Dantanarayana, Surekha Tennakoon, Jérémy Dufloo, James McMahon, Judy J Chang, Vanessa A Evans, Paul J Hertzog, Martin R Jakobsen, Andrew N Harman, Sharon R Lewin, Paul U Cameron

Publikováno v: PLoS Pathogens, Vol 16, Iss 2, p e1008151 (2020)

HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral therapy (ART) because the virus persists in long-lived non-proliferating and proliferating latently infected CD4+ T cells. Latently infected CD4+ T cells d

Externí odkaz: https://doaj.org/article/d333a0dcff84455782c17a524a0f5301

Myeloid dendritic cells induce HIV-1 latency in non-proliferating CD4+ T cells.

Autor: Vanessa A Evans, Nitasha Kumar, Ali Filali, Francesco A Procopio, Oleg Yegorov, Jean-Philippe Goulet, Suha Saleh, Elias K Haddad, Candida da Fonseca Pereira, Paula C Ellenberg, Rafick-Pierre Sekaly, Paul U Cameron, Sharon R Lewin

Publikováno v: PLoS Pathogens, Vol 9, Iss 12, p e1003799 (2013)

Latently infected resting CD4(+) T cells are a major barrier to HIV cure. Understanding how latency is established, maintained and reversed is critical to identifying novel strategies to eliminate latently infected cells. We demonstrate here that co-

Externí odkaz: https://doaj.org/article/f83812028fa3419e87c01200d2ce81e5

Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy

Autor: Sharon R Lewin, Rachel D. Pascoe, Rémi Fromentin, Paul U. Cameron, Ashanti Dantanarayana, Celine Gubser, Thomas A Rasmussen, Lydie Trautman, Ajantha Solomon, Christopher Chiu, Vanessa A. Evans, James H McMahon, Judy Chang, Nicolas Chomont

Publikováno v: Chiu, C Y, Chang, J J, Dantanarayana, A I, Solomon, A, Evans, V A, Pascoe, R, Gubser, C, Trautman, L, Fromentin, R, Chomont, N, McMahon, J H, Cameron, P U, Rasmussen, T A & Lewin, S R 2022, ' Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy ', Journal of Immunology, vol. 208, no. 1, pp. 54-62 . https://doi.org/10.4049/jimmunol.2100367
J Immunol

In people with HIV (PWH) on antiretroviral therapy (ART), immune dysfunction persists, including elevated expression of immune checkpoint (IC) proteins on total and HIV-specific T-cells. Reversing immune exhaustion is one strategy to enhance the elim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1bbff23e6545b23bc265b80b828ee9c
https://pure.au.dk/portal/da/publications/combination-immune-checkpoint-blockade-enhances-il2-and-cd107a-production-from-hivspecific-t-cells-ex-vivo-in-people-living-with-hiv-on-antiretroviral-therapy(b1e04674-c9d9-4b2c-85ec-4cc0210d139f).html

Multiparameter immunohistochemistry analysis of HIV DNA, RNA and immune checkpoints in lymph node tissue

Autor: Mauricio González-Navarro, Jacob D. Estes, Claire Deleage, Paul U. Cameron, Rachel D. Pascoe, Candani Tutuka, Michael Gonzales, Fernanda Torres-Ruiz, Marzena Walkiewicz, Zuwena A. Richardson, Vanessa A. Evans, Samuel Roberts-Thomson, Perla M. Del Río-Estrada, Sharon R Lewin, Gustavo Reyes-Terán

Publikováno v: J Immunol Methods

The main barrier to a cure for HIV is the persistence of long-lived and proliferating latently infected CD4+ T-cells despite antiretroviral therapy (ART). Latency is well characterized in multiple CD4+ T-cell subsets, however, the contribution of reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c3315f779ecb0a80949afacd006268
https://europepmc.org/articles/PMC9036546/

Programmed cell death-1 contributes to the establishment and maintenance of HIV-1 latency

Autor: Paul U. Cameron, Rémi Fromentin, Vanessa A. Evans, Rafick Pierre Sekaly, Ajantha Solomon, Nicolas Chomont, Catriona M. McNeil, Roger Garsia, Ashanti Dantanarayana, Sarah Palmer, Renée M. van der Sluis, Sharon R Lewin

Publikováno v: AIDS. 32:1491-1497

In HIV-infected individuals on antiretroviral therapy (ART), latent HIV is enriched in CD4 T cells expressing immune checkpoint molecules, in particular programmed cell death-1 (PD-1). We therefore assessed the effect of blocking PD-1 on latency, bot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f737999d4213b80b1de8cce0e1ff490
https://doi.org/10.1097/qad.0000000000001849