Splicing targeting drugs highlight intron retention as an actionable vulnerability in advanced prostate cancer

Autor: Chiara Naro, Ambra Antonioni, Vanessa Medici, Cinzia Caggiano, Ariane Jolly, Pierre de la Grange, Pamela Bielli, Maria Paola Paronetto, Claudio Sette

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)

Abstract Background Advanced prostate cancer (PC) is characterized by insensitivity to androgen deprivation therapy and chemotherapy, resulting in poor outcome for most patients. Thus, advanced PC urgently needs novel therapeutic strategies. Mounting

Externí odkaz: https://doaj.org/article/f52fe4f6963343e09f65b470366db281

Fetal exposure to valproic acid dysregulates the expression of autism-linked genes in the developing cerebellum

Autor: Marika Guerra, Vanessa Medici, Robert Weatheritt, Valentina Corvino, Daniela Palacios, Maria Concetta Geloso, Donatella Farini, Claudio Sette

Publikováno v: Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Autism spectrum disorder (ASD) includes a set of highly heritable neurodevelopmental syndromes characterized by social and communication impairment, repetitive behaviour, and intellectual disability. Although mutations in multiple genes have

Externí odkaz: https://doaj.org/article/94bd77eca8a84f9eb44c4d5f2629d607

A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum

Autor: Robert J. Weatheritt, Claudio Sette, Gina La Sala, Vanessa Medici, Francesca Romana Rizzo, Valeria Carola, Benjamin J. Blencowe, Marika Guerra, Vittoria Pagliarini, Chiara Naro, Davide Bonvissuto, Donatella Farini, Daniela Marazziti, Diego Centonze, Alessandra Musella, Eleonora Cesari, Chiara Di Pietro

Publikováno v: Cell reports 31 (2020). doi:10.1016/j.celrep.2020.107703
info:cnr-pdr/source/autori:Donatella Farini, Eleonora Cesari, Robert J. Weatheritt, Gina La Sala, Chiara Naro, Vittoria Pagliarini, Davide Bonvissuto, Vanessa Medici, Marika Guerra, Chiara Di Pietro, Francesca Romana Rizzo, Alessandra Musella, Valeria Carola, Diego Centonze, Benjamin J. Blencowe, Daniela Marazziti, Claudio Sette./titolo:A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum/doi:10.1016%2Fj.celrep.2020.107703/rivista:Cell reports/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:31
Cell Reports, Vol 31, Iss 9, Pp-(2020)

Summary Tight coordination of gene expression in the developing cerebellum is crucial for establishment of neuronal circuits governing motor and cognitive function. However, transcriptional changes alone do not explain all of the switches underlying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0c25922a1198d341d1a8788499a6ae
https://publications.cnr.it/doc/423270

Metformin treatment rescues aberrant mitochondrial activity and oxidative stress status in the brain of female mouse model of Rett syndrome

Autor: Urbinati, Chiara, Zuliani, Ilaria, Daniela, Valenti, Vanessa, Medici, Cosentino, Livia, Vigli, Daniele, DI DOMENICO, Fabio, Perluigi, Marzia, Rosa Anna Vacca, Bianca De Filippis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3686::76c20586f428363a3d0eddaea7349eac
http://hdl.handle.net/11573/1348640

The Anti-Diabetic Drug Metformin Rescues Aberrant Mitochondrial Activity and Restrains Oxidative Stress in a Female Mouse Model of Rett Syndrome

Autor: Rosa Anna Vacca, Ilaria Zuliani, Vanessa Medici, Chiara Urbinati, Bianca De Filippis, Daniela Valenti, Maria Cristina Quattrini, Marzia Perluigi, Donatella Pietraforte, Livia Cosentino, Fabio Di Domenico

Publikováno v: Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 9, Iss 1669, p 1669 (2020)
Journal of Clinical Medicine; Volume 9; Issue 6; Pages: 1669

Metformin is the first-line therapy for diabetes, even in children, and a promising attractive candidate for drug repurposing. Mitochondria are emerging as crucial targets of metformin action both in the periphery and in the brain. The present study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730aa204756bed8318fa21abb58875d7
https://doi.org/10.3390/jcm9061669