Production of the main celiac disease autoantigen by transient expression in Nicotiana benthamiana

Autor: Vanesa Soledad Marin Viegas, Gonzalo Raúl Acevedo, Mariela Paula Bayardo, Fernando Gabriel Chirdo, Silvana ePetruccelli

Publikováno v: Frontiers in Plant Science, Vol 6 (2015)

Celiac Disease (CD) is a gluten sensitive enteropathy that remains widely undiagnosed and implementation of massive screening tests is needed to reduce the long term complications associated to untreated CD. The main CD autoantigen, human tissue tran

Externí odkaz: https://doaj.org/article/29781c9441374242bfe56d001e9d5535

Vacuolar targeting of recombinant antibodies in Nicotiana benthamiana

Autor: Vanesa Soledad Marin Viegas, Silvana Petruccelli, Herta Steinkellner, Silvina Mangano, Carolina Gabriela Ocampo, Jorge Fabricio Lareu, Andreas Loos

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Plant Biotechnology Journal

Plant-based platforms are extensively used for the expression of recombinant proteins, including monoclonal antibodies. However, to harness the approach effectively and leverage it to its full potential, a better understanding of intracellular proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c894aff2f0fa672a490134ec02a069ce
Wiley Online Library