CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology

Autor: Mads N. Olesen, Josefine R. Christiansen, Steen Vang Petersen, Poul Henning Jensen, Wojciech Paslawski, Marina Romero-Ramos, Vanesa Sanchez-Guajardo

Publikováno v: Heliyon, Vol 4, Iss 1 (2018)

We have previously shown that immunological processes in the brain during α-synuclein-induced neurodegeneration vary depending on the presence or absence of cell death. This suggests that the immune system is able to react differently to the differe

Externí odkaz: https://doaj.org/article/5b9e58bc5a2a4fb0b029943aa0c6ee69

Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease.

Autor: Vanesa Sanchez-Guajardo, Fabia Febbraro, Deniz Kirik, Marina Romero-Ramos

Publikováno v: PLoS ONE, Vol 5, Iss 1, p e8784 (2010)

Post-mortem analysis of brains from Parkinson's disease (PD) patients strongly supports microglia activation and adaptive immunity as factors contributing to disease progression. Such responses may be triggered by alpha-synuclein (alpha-syn), which i

Externí odkaz: https://doaj.org/article/2c727cfbabca401197de48183975cf4f

CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology

Autor: Vanesa Sanchez-Guajardo, Marina Romero-Ramos, Josefine R. Christiansen, Poul Henning Jensen, Wojciech Paslawski, Steen V. Petersen, Mads Nikolaj Olesen

Publikováno v: Heliyon
Olesen, M N, Christiansen, J R, Petersen, S V, Jensen, P H, Paslawski, W, Romero-Ramos, M & Sanchez-Guajardo, V 2018, ' CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology ', Heliyon, vol. 4, no. 1, e00513 . https://doi.org/10.1016/j.heliyon.2018.e00513
Heliyon, Vol 4, Iss 1 (2018)

We have previously shown that immunological processes in the brain during α-synuclein-induced neurodegeneration vary depending on the presence or absence of cell death. This suggests that the immune system is able to react differently to the differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245d15eb13b18fdd2f60f598e695bc72
https://pubmed.ncbi.nlm.nih.gov/29560431

α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology

Autor: Vanesa Sanchez-Guajardo, Josefine R. Christiansen, Mads Nikolaj Olesen, Marina Romero-Ramos, Daniel E. Otzen

Publikováno v: Journal of Neuroinflammation
Christiansen, J R, Olesen, M N, Otzen, D E, Romero-Ramos, M & Sanchez-Guajardo, V 2016, ' α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology ', Journal of Neuroinflammation, vol. 13, 74 . https://doi.org/10.1186/s12974-016-0532-8

Background Passive and active immunization with α-synuclein has been shown to be neuroprotective in animal models of Parkinson’s disease. We have previously shown that vaccination with α-synuclein, long before α-synuclein-induced brain pathology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30eeee893f9d2324a75670d50a517a8c
https://pubmed.ncbi.nlm.nih.gov/27055651

α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model

Autor: Vanesa Sanchez-Guajardo, Ambra Annibali, Poul Henning Jensen, Marina Romero-Ramos

Publikováno v: Sanchez-Guajardo, V, Annibali, A, Jensen, P H & Romero-Ramos, M 2013, ' α-Synuclein Vaccination Prevents the Accumulation of Parkinson Disease-Like Pathologic Inclusions in Striatum in Association With Regulatory T Cell Recruitment in a Rat Model ', Journal of Neuropathology and Experimental Neurology, vol. 72, no. 7, pp. 624-45 . https://doi.org/10.1097/NEN.0b013e31829768d2

Human leukocyte antigen-DR induction and lymphocyte infiltrates in the brains of patients with Parkinson disease (PD) and the presence in serum of α-synuclein (α-syn)-specific antibodies suggest that the peripheral immune system may have an active

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9e8064d159ecfcedfd0ebefd2682c3
https://pubmed.ncbi.nlm.nih.gov/23771222