The activity of therapeutic molecular cluster Ag5 is dependent on oxygen level and HIF-1 mediated signalling

Autor: Sophie A. Twigger, Blanca Dominguez, Vanesa Porto, Lina Hacker, Anthony J. Chalmers, Ross Breckenridge, Martin Treder, Adam C. Sedgwick, Fernando Dominguez, Ester M. Hammond

Publikováno v: Redox Biology, Vol 76, Iss , Pp 103326- (2024)

Regions of hypoxia occur in most solid tumours and are known to significantly impact therapy response and patient prognosis. Ag5 is a recently reported silver molecular cluster which inhibits both glutathione and thioredoxin signalling therefore limi

Externí odkaz: https://doaj.org/article/67a59339aad4476cbe985cd7a0f974ef

Abstract 2020: Derived from a platform of innovative therapeutic molecular clusters (TMC), Ag5 is a highly potent and differentiated molecule that promises to be efficacious in hard-to-treat solid cancers

Autor: Martin Treder, Fernando Domínguez, Anxo Vidal, Angela Turrero, David Buceta, Lisandro J. Giovanetti, Vanesa Porto, Carmen Carneiro, Arturo Lopez, Giampaolo Barone, Erea Borrajo, J M. Devida, Félix G. Requejo, Blanca Dominguez

Publikováno v: Cancer Research. 81:2020-2020

Bioenergetics of cancer results in an increased oxidation state and toxic by-products such as reactive oxygen species (ROS). ROS-mediated thiol oxidation of specific sensory proteins triggers the antioxidant response in order to decrease ROS levels a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7c03b85cfc99380ebf3f4333cae8171
https://doi.org/10.1158/1538-7445.am2021-2020

Derived from a Platform of Innovative Therapeutic Molecular Clusters (TMC), Ag5 Is a Highly Potent and Differentiated Molecule That Promises to be Efficacious in Hard-to-Treat Hematological Cancers

Autor: Fernando Domínguez, Blanca Dominguez, Martin Treder, Jose Luis Bello, Arturo López-Quintela, Anxo Vidal, Vanesa Porto González, Erea Borrajo, Vanesa Santos, David Buceta, Carmen Carneiro

Publikováno v: Blood. 136:23-23

[Background on medical need in hematology]Even though significant progress has been made in a number of hematological malignancies in recent years, an unmet medical need still remains in indications such as multiple myeloma (MM), chronic lymphocytic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dd5a16c32d7989802c387437099405e
https://doi.org/10.1182/blood-2020-136618

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Interaction of silver atomic quantum clusters with living organisms: bactericidal effect of Ag3 clusters mediated by disruption of topoisomerase–DNA complexes

Autor: Fernando Domínguez, Begoña García, José M. Leal, Erea Borrajo, Natalia Busto, Cristina Pérez-Arnaiz, M. A. López-Quintela, Vanesa Porto, Jose I. Neissa

Publikováno v: Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname

Essential processes for living cells such as transcription and replication depend on the formation of specific protein–DNA recognition complexes. Proper formation of such complexes requires suitable fitting between the protein surface and the DNA s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4787eb48c007eb70e2b2e47b8c9cf0e
http://hdl.handle.net/10347/23059