Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Vanesa G. Martinez"'
Autor:
Vanesa G. Martinez, Sadhbh O'Neill, Josephine Salimu, Susan Breslin, Aled Clayton, John Crown, Lorraine O'Driscoll
Publikováno v:
OncoImmunology, Vol 6, Iss 12 (2017)
Neuromedin U (NmU) -a neuropeptide belonging to the neuromedin family– plays a substantial role in HER2-positive breast cancer, correlating with increased aggressiveness, resistance to HER2-targeted therapies and overall significantly poorer outcom
Externí odkaz:
https://doaj.org/article/596b2cf4b1194c95b866c6402663e962
Publikováno v:
International Journal of Cancer. 140:2771-2784
Neuromedin U (NmU) is a neuropeptide belonging to the neuromedin family. Recently, we reported a significant association between NmU and breast cancer, particularly correlating with increased aggressiveness, resistance to HER2-targeted therapies and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e745b18ffb1999e4dd137e84e5fda050
https://doi.org/10.1002/ijc.30705
https://doi.org/10.1002/ijc.30705
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Due to limited availability of pharmacological therapies, triple-negative breast cancer (TNBC) is the subtype with worst outcome. We hypothesised that 2-Deoxy-D-Glucose (2-DG), a glucose analogue, may hold potential as a therapy for particularly aggr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4144a8630068c6d5e4481ef0e65c5b9
https://doi.org/10.1038/s41598-019-39789-9
https://doi.org/10.1038/s41598-019-39789-9
Publikováno v:
Clinical Chemistry. 61:471-482
BACKGROUNDNeuromedin U (NmU) belongs to the neuromedin family, comprising a series of neuropeptides involved in the gut–brain axis and including neuromedins B and C (bombesin-like), K (neurokinin B), L (neurokinin A or neurotensin), N, S, and U.CON
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871e7a8be7846d76631050cdb6965de1
https://doi.org/10.1373/clinchem.2014.231753
https://doi.org/10.1373/clinchem.2014.231753
Autor:
Susan Breslin, Vanesa G. Martinez, Josephine Salimu, Aled Clayton, Sadhbh O’Neill, John Crown, Lorraine O'Driscoll
Publikováno v:
Oncoimmunology
OncoImmunology, Vol 6, Iss 12 (2017)
OncoImmunology, Vol 6, Iss 12 (2017)
Neuromedin U (NmU) -a neuropeptide belonging to the neuromedin family– plays a substantial role in HER2-positive breast cancer, correlating with increased aggressiveness, resistance to HER2-targeted therapies and overall significantly poorer outcom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3e8160390b12dceeb925f1928829c9
https://pubmed.ncbi.nlm.nih.gov/29209569
https://pubmed.ncbi.nlm.nih.gov/29209569
Autor:
Martin Clynes, Patrick Gammell, John R. W. Masters, Niall Barron, Joanne Keenan, Alex Freeman, Vanesa G. Martinez
Publikováno v:
The Prostate. 72:1193-1199
BACKGROUND Radical prostatectomy cures the majority of men with clinically localized disease, but up to 30% of men relapse with rising serum PSA levels. Stage, Gleason grade, and pre-operative PSA levels are associated with outcome but do not accurat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a4c8d1dc97b6a6c9fe0e12b2353fba5
https://doi.org/10.1002/pros.22469
https://doi.org/10.1002/pros.22469
Publikováno v:
British Journal of Cancer
The cytochrome P450 CYP1B1 is consistently overexpressed in tumour cells as compared to their normal counterparts, but its precise role in drug resistance is yet to be defined. It has been reported that transfection of CYP1B1 results in increased res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da50defd2adea65bb18f24419a404600
https://doi.org/10.1038/sj.bjc.6604195
https://doi.org/10.1038/sj.bjc.6604195
Autor:
Robert O'Connor, Eoin Ryan, Helena Joyce, Jai Prakash Mehta, Vanesa G. Martinez, Lorraine O'Driscoll, Elaine Kenny, Susan Kennedy, Martin Clynes, Patrick Gammell, John Crown, Padraig Doolan
Publikováno v:
Breast Cancer Research and Treatment. 110:521-530
The complex role of drug metabolism-related enzymes and their possible influence in cancer development, treatment and outcome has not yet been completely elucidated. There is evidence that these enzymes can activate certain environmental procarcinoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb42dd52c248695329b33cc01adb5ee
https://doi.org/10.1007/s10549-007-9739-9
https://doi.org/10.1007/s10549-007-9739-9
Autor:
Berta Denduchis, Vanesa G. Martinez, Selva B. Cigorraga, Eliana Herminia Pellizzari, Carlota Wolfenstein-Todel, M. Mercedes Iglesias, Emilce S. Diaz, Livia Lustig
Publikováno v:
Glycobiology. 14:127-137
Galectin-1 (Gal-1), a beta galactoside-binding lectin, is involved in multiple biological functions, such as cell adhesion, apoptosis, and metastasis. On the basis of its ability to interact with extracellular matrix (ECM) glycoproteins, we investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1e8790bc1526267bec83af13cd7022
https://doi.org/10.1093/glycob/cwh025
https://doi.org/10.1093/glycob/cwh025
Publikováno v:
Cancer Research. 76:LB-116
HER-targeted therapies are an attractive approach for HER2-overexpressing breast cancer; unfortunately, not all tumours are responsive and some that initially respond later develop resistance to therapy. Such drug-resistance is often associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd743f7d960eb990230ba507eaf48fea
https://doi.org/10.1158/1538-7445.am2016-lb-116
https://doi.org/10.1158/1538-7445.am2016-lb-116