Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Vandna Munshi"'
Autor:
Ming-Tain Lai, Vandna Munshi, Meiqing Lu, MeiZhen Feng, Renee Hrin-Solt, Philip M. McKenna, Daria J. Hazuda, Michael D. Miller
Publikováno v:
Viruses, Vol 8, Iss 10, p 263 (2016)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a mainstay of therapy for human immunodeficiency type 1 virus (HIV-1) infections. However, their effectiveness can be hampered by the emergence of resistant mutations. To aid in designing e
Externí odkaz:
https://doaj.org/article/27cb96f9928d41d1be3ad14cb9d69880
Autor:
Jay A. Grobler, Paul Zuck, Victor N. Uebele, Jeffrey D. Hermes, Vandna Munshi, Gregory C. Adam, Juncai Meng, Ming-Tain Lai, John A. McCauley, Eric N. Johnson
Publikováno v:
SLAS Discovery. 20:606-615
HIV-1 protease (PR) represents one of the primary targets for developing antiviral agents for the treatment of HIV-infected patients. To identify novel PR inhibitors, a label-free, high-throughput mass spectrometry (HTMS) assay was developed using th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d373e81f6536d1070008ce79b26956
https://doi.org/10.1177/1087057115570838
https://doi.org/10.1177/1087057115570838
Autor:
Philip M. McKenna, Meizhen Feng, Renee Hrin-Solt, Michael D. Miller, Meiqing Lu, Daria J. Hazuda, Vandna Munshi, Ming-Tain Lai
Publikováno v:
Viruses
Viruses; Volume 8; Issue 10; Pages: 263
Viruses, Vol 8, Iss 10, p 263 (2016)
Viruses; Volume 8; Issue 10; Pages: 263
Viruses, Vol 8, Iss 10, p 263 (2016)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a mainstay of therapy for human immunodeficiency type 1 virus (HIV-1) infections. However, their effectiveness can be hampered by the emergence of resistant mutations. To aid in designing e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9028c48e200868a8863746e354ec0c0
http://europepmc.org/articles/PMC5086599
http://europepmc.org/articles/PMC5086599
Autor:
Robert P. Gomez, Ming-Tain Lai, Jay A. Grobler, Peter J. Felock, Renee Hrin, Meiqing Lu, Daria J. Hazuda, Michael D. Miller, Philip M. McKenna, Vandna Munshi, Georgia B. McGaughey, Youwei Yan, Neville J. Anthony, Sanjeev Munshi, Theresa M. Williams, Ying-Jie Wang
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:3324-3335
MK-6186 is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) which displays subnanomolar potency against wild-type (WT) virus and the two most prevalent NNRTI-resistant RT mutants (K103N and Y181C) in biochemical assays. In addition, it s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561b3281c8a4f7dea6d1c2cf6e7309a2
https://doi.org/10.1128/aac.00102-12
https://doi.org/10.1128/aac.00102-12
Autor:
Yuexia Liang, Daniel DeStefano, Samson M. Jolly, Georgia B. McGaughey, Joe P. Vacca, Bang-Lin Wan, Michael W. Miller, Robert P. Gomez, Youwei Yan, Sinoeun Touch, Neville J. Anthony, Robert M. Tynebor, Ming-Tain Lai, Rosa I. Sanchez, Vandna Munshi, Thomas J. Tucker, Theresa M. Williams, Peter J. Felock, Brenda Paton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7344-7350
Next generation NNRTIs are sought which possess both broad spectrum antiviral activity against key mutant strains and a high genetic barrier to the selection of new mutant viral strains. Pyridones were evaluated as an acyclic conformational constrain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b31490ebe226d08d8789ee8cd109a3
https://doi.org/10.1016/j.bmcl.2011.10.027
https://doi.org/10.1016/j.bmcl.2011.10.027
Design, Synthesis, and X-ray Crystallographic Analysis of a Novel Class of HIV-1 Protease Inhibitors
Autor:
Andrew T. McPhail, Chih-Hung Wang, Christine Burlein, A. K. Ganguly, Yong Zhang, Steven S. Carroll, Corey Strickland, Dipshikha Biswas, Danielle Caroccia, Peter Orth, Vandna Munshi, S. Alluri, Eunhee Kang
Publikováno v:
Journal of Medicinal Chemistry. 54:7176-7183
In the present paper, design, synthesis, X-ray crystallographic analysis, and HIV-1 protease inhibitory activities of a novel class of compounds are disclosed. Compounds 28-30, 32, 35, and 40 were synthesized and found to be inhibitors of the HIV-1 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0047a6f703f119d33fc72d33efccd9
https://doi.org/10.1021/jm200778q
https://doi.org/10.1021/jm200778q
Autor:
Michael D. Miller, Ye Mei, Marie H. Loughran, Jay A. Grobler, Winnie Ngo, Meiqing Lu, Vandna Munshi, Peter D. Williams, Tracy L. Diamond, Daria J. Hazuda, Ming-Tain Lai, Christine Burlein
Publikováno v:
Protein Expression and Purification. 71:231-239
Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) plays an essential role in the life cycle of the virus. Therefore, RT has been a primary target in the development of antiviral agents against HIV-1. Given the prevalence of resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c474d787ddd4971895efd8b11c225e6
https://doi.org/10.1016/j.pep.2010.01.001
https://doi.org/10.1016/j.pep.2010.01.001
Autor:
Theresa M. Williams, Youwei Yan, Michael W. Miller, Joseph P. Vacca, Rebecca Perlow-Poehnelt, Bang-Lin Wan, Ming-Tain Lai, Sridhar Prasad, Saggar Sandeep A, Georgia B. McGaughey, Maricel Torrent, Robert M. Tynebor, Rosa I. Sanchez, John T. Sisko, Yuexia Liang, Peter J. Felock, Jessica A. Flynn, Thomas J. Tucker, Meiquing Liu, Gregory Moyer, Vandna Munshi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2959-2966
Using a combination of traditional Medicinal Chemistry/SAR analysis, crystallography, and molecular modeling, we have designed and synthesized a series of novel, highly potent NNRTIs that possess broad antiviral activity against a number of key clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f89230b4fd01e13b8d56f9729d01d8e
https://doi.org/10.1016/j.bmcl.2008.03.064
https://doi.org/10.1016/j.bmcl.2008.03.064
Autor:
Ming-Tain Lai, Vandna Munshi, Peter J. Felock, Daria J. Hazuda, Michael D. Miller, Meiqing Lu, Richard J. O. Barnard
Publikováno v:
Analytical Biochemistry. 374:121-132
Reverse transcriptase (RT) plays an essential role in the HIV-1 replication process, which converts a single-strand RNA into a double-strand DNA via polymerase and RNase H activities. Therefore, inhibition of RT has been one of the primary therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32c96b63dde749f980c3e61a57b6e73
https://doi.org/10.1016/j.ab.2007.10.004
https://doi.org/10.1016/j.ab.2007.10.004
Autor:
Michael D. Miller, Krista Getty, Michael A. Parniak, Vandna Munshi, Bradley Feuston, Julie Krueger, Cathryn A. Shaw-Reid, Daria J. Hazuda, Dale W. Lewis
Publikováno v:
Biochemistry. 44:1595-1606
Although HIV-1 reverse transcriptase (RT) DNA polymerase and ribonuclease H (RNase H) activities reside in spatially distinct domains of the enzyme, inhibitors that bind in the RT polymerase domain can affect RNase H activity. We used both gel assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf79cb98ffac14d7ef0ae70ed742f513
https://doi.org/10.1021/bi0486740
https://doi.org/10.1021/bi0486740