Deep mutational scanning of CYP2C19 in human cells reveals a substrate specificity-abundance tradeoff.

Autor: Boyle GE; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Sitko KA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Galloway JG; Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Haddox HK; Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Bianchi AH; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Dixon A; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Wheelock MK; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Vandi AJ; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Wang ZR; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Thomson RES; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4067, Australia., Garge RK; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA 98195, USA., Rettie AE; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA., Rubin AF; Bioinformatics Division, Walter and Eliza Hall Institute, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia., Geck RC; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Gillam EMJ; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4067, Australia., DeWitt WS; Department of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA 94720, USA., Matsen FA 4th; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Howard Hughes Medical Institute, Seattle, WA 98109, USA.; Department of Statistics, University of Washington, Seattle, WA 98195, USA., Fowler DM; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.

Publikováno v: Genetics [Genetics] 2024 Nov 06; Vol. 228 (3).