Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

Autor: Dejager, L, Dendoncker, K, Eggermont, M, Souffriau, J, Van Hauwermeiren, F, Willart, M, Van Wonterghem, E, Naessens, T, Ballegeer, M, Vandevyver, S, Hammad, H, Lambrecht, B, De Bosscher, K, Grooten, J, Libert, C

Publikováno v: In Mucosal Immunology November 2015 8(6):1212-1225

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium.

Autor: Souffriau J; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Timmermans S; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Vanderhaeghen T; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Wallaeys C; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Van Looveren K; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Aelbrecht L; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Dewaele S; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Vandewalle J; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Goossens E; Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Verbanck S; Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Boyen F; Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Eggermont M; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., De Commer L; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.; VIB-KU Leuven Center for Microbiology, Leuven, Belgium., De Rycke R; Department of Biomedical Molecular Biology and Expertise Centre for Transmission Electron Microscopy, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research and BioImaging Core, VIB, Ghent, Belgium., De Bruyne M; Department of Biomedical Molecular Biology and Expertise Centre for Transmission Electron Microscopy, Ghent University, Ghent, Belgium.; VIB Center for Inflammation Research and BioImaging Core, VIB, Ghent, Belgium., Tito R; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.; VIB-KU Leuven Center for Microbiology, Leuven, Belgium., Ballegeer M; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Vandevyver S; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Velho T; Instituto Gulbenkian de Ciência, Oeiras, Portugal., Moita LF; Instituto Gulbenkian de Ciência, Oeiras, Portugal., Hochepied T; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., De Bosscher K; VIB Center for Medical Biotechnology, Ghent, Belgium.; Department of Biochemistry, Ghent University, Ghent, Belgium., Raes J; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.; VIB-KU Leuven Center for Microbiology, Leuven, Belgium., Van Immerseel F; Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Beyaert R; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Libert C; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2020 Oct 07; Vol. 12 (10), pp. e11917. Date of Electronic Publication: 2020 Sep 11.

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

Autor: Dendoncker K; Mouse Genetics in Inflammation, VIB Center for Inflammation Research, 9052 Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium., Timmermans S; Mouse Genetics in Inflammation, VIB Center for Inflammation Research, 9052 Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium., Vandewalle J; Mouse Genetics in Inflammation, VIB Center for Inflammation Research, 9052 Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium., Eggermont M; Mouse Genetics in Inflammation, VIB Center for Inflammation Research, 9052 Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium., Lempiäinen J; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland., Paakinaho V; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland., Van Hamme E; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium.; Bio Imaging Core, VIB Center for Inflammation Research, 9052 Ghent, Belgium., Dewaele S; Mouse Genetics in Inflammation, VIB Center for Inflammation Research, 9052 Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium., Vandevyver S; Mouse Genetics in Inflammation, VIB Center for Inflammation Research, 9052 Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium., Ballegeer M; Mouse Genetics in Inflammation, VIB Center for Inflammation Research, 9052 Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium., Souffriau J; Mouse Genetics in Inflammation, VIB Center for Inflammation Research, 9052 Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium., Van Wyngene L; Mouse Genetics in Inflammation, VIB Center for Inflammation Research, 9052 Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium., Van Looveren K; Mouse Genetics in Inflammation, VIB Center for Inflammation Research, 9052 Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium., Vanderhaeghen T; Mouse Genetics in Inflammation, VIB Center for Inflammation Research, 9052 Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium., Beyaert R; Mouse Genetics in Inflammation, VIB Center for Inflammation Research, 9052 Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium., De Bosscher K; Medical Biotechnology Center, VIB, 9000 Ghent, Belgium.; Department of Biochemistry, Ghent University, 9000 Ghent, Belgium., Palvimo JJ; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland., Van Montagu M; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; marc.vanmontagu@ugent.be claude.libert@irc.VIB-UGent.be.; Center for Plant Systems Biology, VIB, 9052 Ghent, Belgium.; International Plant Biotechnology Outreach, VIB, 9052 Ghent, Belgium., Libert C; Mouse Genetics in Inflammation, VIB Center for Inflammation Research, 9052 Ghent, Belgium; marc.vanmontagu@ugent.be claude.libert@irc.VIB-UGent.be.; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jun 25; Vol. 116 (26), pp. 12942-12951. Date of Electronic Publication: 2019 Jun 10.

The Interaction of Vasopressin with Hormones of the Hypothalamo–Pituitary–Adrenal Axis: The Significance for Therapeutic Strategies in Cardiovascular and Metabolic Diseases.

Autor: Szczepanska-Sadowska, Ewa¹ (AUTHOR) eszczepanska@wum.edu.pl, Czarzasta, Katarzyna¹ (AUTHOR), Bogacki-Rychlik, Wiktor¹ (AUTHOR), Kowara, Michał¹ (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 13, p7394. 33p.

Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor.

Autor: Petta I; Receptor Research Laboratories, Cytokine Receptor Lab, VIB, Center for Medical Biotechnology, Ghent, Belgium.; Department of Biochemistry, Ghent University, Ghent, Belgium.; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Bougarne N; Receptor Research Laboratories, Cytokine Receptor Lab, VIB, Center for Medical Biotechnology, Ghent, Belgium.; Department of Biochemistry, Ghent University, Ghent, Belgium.; Receptor Research Laboratories, Nuclear Receptor Lab, VIB, Medical Biotechnology Center, Ghent, Belgium., Vandewalle J; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Dejager L; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Vandevyver S; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Ballegeer M; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Desmet S; Receptor Research Laboratories, Cytokine Receptor Lab, VIB, Center for Medical Biotechnology, Ghent, Belgium.; Department of Biochemistry, Ghent University, Ghent, Belgium.; Receptor Research Laboratories, Nuclear Receptor Lab, VIB, Medical Biotechnology Center, Ghent, Belgium., Thommis J; Receptor Research Laboratories, Cytokine Receptor Lab, VIB, Center for Medical Biotechnology, Ghent, Belgium.; Department of Biochemistry, Ghent University, Ghent, Belgium.; Receptor Research Laboratories, Nuclear Receptor Lab, VIB, Medical Biotechnology Center, Ghent, Belgium., De Cauwer L; Receptor Research Laboratories, Cytokine Receptor Lab, VIB, Center for Medical Biotechnology, Ghent, Belgium.; Department of Biochemistry, Ghent University, Ghent, Belgium.; Receptor Research Laboratories, Nuclear Receptor Lab, VIB, Medical Biotechnology Center, Ghent, Belgium., Lievens S; Receptor Research Laboratories, Cytokine Receptor Lab, VIB, Center for Medical Biotechnology, Ghent, Belgium.; Department of Biochemistry, Ghent University, Ghent, Belgium., Libert C; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Tavernier J; Receptor Research Laboratories, Cytokine Receptor Lab, VIB, Center for Medical Biotechnology, Ghent, Belgium.; Department of Biochemistry, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., De Bosscher K; Receptor Research Laboratories, Cytokine Receptor Lab, VIB, Center for Medical Biotechnology, Ghent, Belgium. karolien.debosscher@vib-ugent.be.; Department of Biochemistry, Ghent University, Ghent, Belgium. karolien.debosscher@vib-ugent.be.; Receptor Research Laboratories, Nuclear Receptor Lab, VIB, Medical Biotechnology Center, Ghent, Belgium. karolien.debosscher@vib-ugent.be.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium. karolien.debosscher@vib-ugent.be.

Publikováno v: Scientific reports [Sci Rep] 2017 Aug 21; Vol. 7 (1), pp. 8941. Date of Electronic Publication: 2017 Aug 21.