Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.

Autor: Himmelbauer MK; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Bajrami B; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Basile R; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Capacci A; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Chen T; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Choi CK; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Gilfillan R; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Gonzalez-Lopez de Turiso F; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Gu C; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Hoemberger M; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Johnson DS; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Jones JH; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Kadakia E; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Kirkland M; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Lin EY; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Liu Y; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Ma B; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Magee T; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Mantena S; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Marx IE; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Metrick CM; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Mingueneau M; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Murugan P; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Muste CA; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Nadella P; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Nevalainen M; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Parker Harp CR; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Pattaropong V; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Pietrasiewicz A; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Prince RJ; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Purgett TJ; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Santoro JC; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Schulz J; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Sciabola S; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Tang H; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Vandeveer HG; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Wang T; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Yousaf Z; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Helal CJ; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Hopkins BT; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 May 23; Vol. 67 (10), pp. 8122-8140. Date of Electronic Publication: 2024 May 07.