Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.

Autor: Vandermeulen, Lina¹ (AUTHOR), Geric, Ivana^2,3 (AUTHOR), Fumagalli, Laura^4,5 (AUTHOR), Kreir, Mohamed⁶ (AUTHOR), Lu, Ashley^2,3 (AUTHOR), Nonneman, Annelies¹ (AUTHOR), Premereur, Jessie^4,5 (AUTHOR), Wolfs, Leen^2,3 (AUTHOR), Policarpo, Rafaela^1,2,3 (AUTHOR), Fattorelli, Nicola^2,3 (AUTHOR), De Bondt, An⁷ (AUTHOR), Van Den Wyngaert, Ilse⁷ (AUTHOR), Asselbergh, Bob^8,9 (AUTHOR), Fiers, Mark^2,3,10 (AUTHOR), De Strooper, Bart^2,3,10 (AUTHOR), d'Ydewalle, Constantin¹ (AUTHOR) cvanoutr@its.jnj.com, Mancuso, Renzo^2,3,4,5 (AUTHOR) Renzo.mancuso@uantwerpen.vib.be

Publikováno v: Molecular Neurodegeneration. 4/24/2024, Vol. 19 Issue 1, p1-25. 25p.

Cyclase-associated protein 2 dimerization regulates cofilin in synaptic plasticity and Alzheimer's disease

Autor: Pelucchi, Silvia, Vandermeulen, Lina, Pizzamiglio, Lara, Aksan, Bahar, Yan, Jing, Konietzny, Anja, Bonomi, Elisa, Borroni, Barbara, Padovani, Alessandro, Rust, Marco B, Di Marino, Daniele, Mikhaylova, Marina, Mauceri, Daniela, Antonucci, Flavia, Edefonti, Valeria, Gardoni, Fabrizio, Di Luca, Monica, Marcello, Elena

Publikováno v: Brain Communications

Regulation of actin cytoskeleton dynamics in dendritic spines is crucial for learning and memory formation. Hence, defects in the actin cytoskeleton pathways are a biological trait of several brain diseases, including Alzheimer's disease. Here, we de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::003da1f7c1858529042b758a518f8eec
http://europepmc.org/articles/PMC7566557

Additional file 1 of Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain

Autor: Lundgren, Jolanta, Vandermeulen, Lina, Sandebring-Matton, Anna, Saheeb Ahmed, Winblad, Bengt, Luca, Monica Di, Tjernberg, Lars, Marcello, Elena, Frykman, Susanne

Additional file 1. Proximity ligation assay showing co-localization of ADAM10 and BACE1 with their substrate APP in adult rat brain. Adult rat brain hippocampal sections were subjected to PLA and each signal (brown dot) generated denotes two proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be5eb9315747988b2a494dea7845688

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AMYLOID-BETA DEGRADATION BY HUMAN ASTROCYTES IS IMPAIRED BY APOJ AND APOE

Autor: Mulder, Sandra D., Vandermeulen, Lina, Scheltens, Philip, Blankenstein, Marinus A., Veerhuis, Robert

Publikováno v: In Alzheimer's & Dementia: The Journal of the Alzheimer's Association July 2014 10(4) Supplement:P638-P638