Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease.

Autor: Eubanks E; Department of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA., VanderSleen K; Department of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA., Mody J; Department of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA., Patel N; Department of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA., Sacks B; Department of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA., Farahani MD; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA., Wang J; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA., Elliott J; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA., Jaber N; Department of Cell Biology and Neuroscience & Institute for Quantitative Biomedicine, Rutgers University, Piscataway, NJ 08854, USA., Akçimen F; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA., Bandres-Ciga S; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA., Helweh F; UNAM-National Nanotechnology Research Center and Institute of Materials Science & Nanotechnology, Bilkent University, Ankara, Turkey., Liu J; Department of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA., Archakam S; Department of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA., Kimelman R; Department of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA., Sharma B; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA., Socha P; Department of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA., Guntur A; Department of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA., Bartels T; UK Dementia Research Institute, University College London, London W1T 7NF, United Kingdom., Dettmer U; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Mouradian MM; Department of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA., Bahrami AH; UNAM-National Nanotechnology Research Center and Institute of Materials Science & Nanotechnology, Bilkent University, Ankara, Turkey.; Living Matter Physics, Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany., Dai W; Department of Cell Biology and Neuroscience & Institute for Quantitative Biomedicine, Rutgers University, Piscataway, NJ 08854, USA., Baum J; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA., Shi Z; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA., Hardy J; UK Dementia Research Institute, University College London, London W1T 7NF, United Kingdom.; Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.; National Institute for Health Research (NIHR) University College London Hospitals Biomedical Research Centre, London W1T 7DN, UK.; Institute for Advanced Study, The Hong Kong University of Science and Technology, Hong Kong SAR, China., Kara E; Department of Neurology, Robert Wood Johnson Medical School, Institute for Neurological Therapeutics at Rutgers, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 01. Date of Electronic Publication: 2024 Sep 01.