Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.

Autor: Parr BT; Genentech, South San Francisco, California 94080, United States., Pastor R; Genentech, South San Francisco, California 94080, United States., Sellers BD; Genentech, South San Francisco, California 94080, United States., Pei Z; Genentech, South San Francisco, California 94080, United States., Jaipuri FA; NewLink Genetics, Ames, Iowa 50010, United States., Castanedo GM; Genentech, South San Francisco, California 94080, United States., Gazzard L; Genentech, South San Francisco, California 94080, United States., Kumar S; NewLink Genetics, Ames, Iowa 50010, United States., Li X; NewLink Genetics, Ames, Iowa 50010, United States., Liu W; Genentech, South San Francisco, California 94080, United States., Mendonca R; Genentech, South San Francisco, California 94080, United States., Pavana RK; NewLink Genetics, Ames, Iowa 50010, United States., Potturi H; NewLink Genetics, Ames, Iowa 50010, United States., Shao C; Pharmaron, Beijing 100176, People's Republic of China., Velvadapu V; NewLink Genetics, Ames, Iowa 50010, United States., Waldo JP; NewLink Genetics, Ames, Iowa 50010, United States., Wu G; Pharmaron, Beijing 100176, People's Republic of China., Yuen PW; Pharmaron, Beijing 100176, People's Republic of China., Zhang Z; NewLink Genetics, Ames, Iowa 50010, United States., Zhang Y; Pharmaron, Beijing 100176, People's Republic of China., Harris SF; Genentech, South San Francisco, California 94080, United States., Oh AJ; Genentech, South San Francisco, California 94080, United States., DiPasquale A; Genentech, South San Francisco, California 94080, United States., Dement K; Genentech, South San Francisco, California 94080, United States., La H; Genentech, South San Francisco, California 94080, United States., Goon L; Genentech, South San Francisco, California 94080, United States., Gustafson A; Genentech, South San Francisco, California 94080, United States., VanderPorten EC; Genentech, South San Francisco, California 94080, United States., Mautino MR; NewLink Genetics, Ames, Iowa 50010, United States., Liu Y; Genentech, South San Francisco, California 94080, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Mar 04; Vol. 11 (4), pp. 541-549. Date of Electronic Publication: 2020 Mar 04 (Print Publication: 2020).

Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2).

Autor: Lovitt B; Biochemical Pharmacology and Early Leads, Genentech, Inc.,One DNA Way, South San Francisco, California 90480, USA., Vanderporten EC, Sheng Z, Zhu H, Drummond J, Liu Y

Publikováno v: Biochemistry [Biochemistry] 2010 Apr 13; Vol. 49 (14), pp. 3092-100.

Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.

Autor: Fucini RV; Department of Biology, Sunesis Pharmaceuticals, Inc., 395 Oyster Point Boulevard Suite 400, South San Francisco, CA 94080, USA. rfucini@sunesis.com, Hanan EJ, Romanowski MJ, Elling RA, Lew W, Barr KJ, Zhu J, Yoburn JC, Liu Y, Fahr BT, Fan J, Lu Y, Pham P, Choong IC, VanderPorten EC, Bui M, Purkey HE, Evanchik MJ, Yang W

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Oct 15; Vol. 18 (20), pp. 5648-52. Date of Electronic Publication: 2008 Aug 29.