Transient Receptor Potential Melastatin 7 (TRPM7) Ion Channel Inhibitors: Preliminary SAR and Conformational Studies of Xenicane Diterpenoids from the Hawaiian Soft Coral Sarcothelia edmondsoni .

Autor: Yao G; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.; Chemistry and Biochemistry, Hawaii Pacific University, Kaneohe, Hawaii 96744, United States., Parris MR; Department of Chemistry & Biochemistry, Baylor University, Waco, Texas 76798-7348, United States., Kuo WC; Chemistry and Biochemistry, Hawaii Pacific University, Kaneohe, Hawaii 96744, United States., Pörzgen P; Chemistry and Biochemistry, Hawaii Pacific University, Kaneohe, Hawaii 96744, United States., Castillo B; Chemistry and Biochemistry, Hawaii Pacific University, Kaneohe, Hawaii 96744, United States., Mason ES; Department of Chemistry & Biochemistry, Baylor University, Waco, Texas 76798-7348, United States., Chinchilla A; Department of Chemistry & Biochemistry, Baylor University, Waco, Texas 76798-7348, United States., Huang J; Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen's Medical Center, Honolulu, Hawaii 96813, United States., Suzuki S; Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen's Medical Center, Honolulu, Hawaii 96813, United States., Ross R; Chemistry and Biochemistry, Hawaii Pacific University, Kaneohe, Hawaii 96744, United States., Akana E; Chemistry and Biochemistry, Hawaii Pacific University, Kaneohe, Hawaii 96744, United States., Vander Schuit S; Chemistry and Biochemistry, Hawaii Pacific University, Kaneohe, Hawaii 96744, United States., Miller SP; Department of Pediatrics, University of British Columbia and BC Children's Hospital, Vancouver, British Columbia V6H 3N1, Canada., Penner R; Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen's Medical Center, Honolulu, Hawaii 96813, United States., Sun HS, Feng ZP, Hull KG; Department of Chemistry & Biochemistry, Baylor University, Waco, Texas 76798-7348, United States.; The Baylor Synthesis and Drug-Lead Discovery Laboratory, Baylor University, Waco, Texas 76798, United States., Romo D; Department of Chemistry & Biochemistry, Baylor University, Waco, Texas 76798-7348, United States., Fleig A; Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen's Medical Center, Honolulu, Hawaii 96813, United States., Horgen FD; Chemistry and Biochemistry, Hawaii Pacific University, Kaneohe, Hawaii 96744, United States.

Publikováno v: Journal of natural products [J Nat Prod] 2024 Apr 26; Vol. 87 (4), pp. 783-797. Date of Electronic Publication: 2024 Mar 27.