Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Vandana Sampathkumar"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The neotenous, or delayed, development of primate neurons, particularly human ones, is thought to underlie primate-specific abilities like cognition. We tested whether synaptic development follows suit—would synapses, in absolute time, dev
Externí odkaz:
https://doaj.org/article/7d42955808934e489f229d8857be2d07
Autor:
Sean Foxley, Vandana Sampathkumar, Vincent De Andrade, Scott Trinkle, Anastasia Sorokina, Katrina Norwood, Patrick La Riviere, Narayanan Kasthuri
Publikováno v:
NeuroImage, Vol 238, Iss , Pp 118250- (2021)
Mammalian neurons operate at length scales spanning six orders of magnitude; they project millimeters to centimeters across brain regions, are composed of micrometer-scale-diameter myelinated axons, and ultimately form nanometer scale synapses. Captu
Externí odkaz:
https://doaj.org/article/73bdcc10a36040c09f412a4a4d39845b
Autor:
Pierre De Rossi, Toshihiro Nomura, Robert J. Andrew, Nicolas Y. Masse, Vandana Sampathkumar, Timothy F. Musial, Ari Sudwarts, Aleksandra J. Recupero, Thomas Le Metayer, Mitchell T. Hansen, Ha-Na Shim, Sofia V. Krause, David J. Freedman, Vytas P. Bindokas, Narayanan Kasthuri, Daniel A. Nicholson, Anis Contractor, Gopal Thinakaran
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3520-3535.e7 (2020)
Summary: BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer disease risk factor. Here, we investigate BIN1 function in the brain using conditional knockout (cKO) models. Loss of neuronal Bin1 expression results in
Externí odkaz:
https://doaj.org/article/3ee20aa26dbb4398a318c588047a8aa8
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Aggregatibacter actinomycetemcomitans leukotoxin (LtxA) is a major virulence factor that kills leukocytes permitting it’s escape from host immune surveillance. A. actinomycetemcomitans strains can produce high or low levels of toxin. Genet
Externí odkaz:
https://doaj.org/article/f58538ed61814f1bbf41a9e65401a4f6
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151361 (2016)
Leukotoxin (Ltx) is a prominent virulence factor produced by Aggregatibacter actinomycetemcomitans, an oral microorganism highly associated with aggressive periodontitis. Ltx compromises host responsiveness by altering the viability of neutrophils, l
Externí odkaz:
https://doaj.org/article/31cdc75c24d24f2dbd7d12e9245d3eb2
Autor:
Michael T Karwacki, Daniel E Kadouri, Meriem Bendaoud, Era A Izano, Vandana Sampathkumar, Thomas J Inzana, Jeffrey B Kaplan
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63844 (2013)
Cell-free extracts isolated from colony biofilms of Actinobacillus pleuropneumoniae serotype 5 were found to inhibit biofilm formation by Staphylococcus aureus, S. epidermidis and Aggregatibacter actinomycetemcomitans, but not by A. pleuropneumoniae
Externí odkaz:
https://doaj.org/article/e4620353512342f6a07139fb5c0547a8
Autor:
Vandana Sampathkumar, Ashleigh Polo, Lin Piao, Lorenzo Crowley, Haotian Gan, Hemraj Dodiya, Sangram Sisodia, Willard Sharp, Alfredo Garcia, Narayanan Kasthuri
Publikováno v:
Physiology. 38
Sleep apnea, a clinical condition characterized by repetitive pauses in breathing that cause intermittent hypoxia (IH), affects a billion people worldwide, increases the risk for mild cognitive impairment, and is estimated to occur in up to 50% of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f13b29be397cd85172ea6139bc150588
https://doi.org/10.1152/physiol.2023.38.s1.5734712
https://doi.org/10.1152/physiol.2023.38.s1.5734712
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Neurons in the thalamic reticular nucleus (TRN) are a primary source of inhibition to the dorsal thalamus and, as they are innervated in part by the cortex, are a means of corticothalamic regulation. Previously, cortical inputs to the TRN were though
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90940206a972a5d3aef517909b44235
https://doi.org/10.1073/pnas.2205209119
https://doi.org/10.1073/pnas.2205209119
Publikováno v:
European Journal of Neuroscience. 53:750-762
Many studies exist of thalamocortical synapses in primary sensory cortex, but much less in known about higher-order thalamocortical projections to higher-order cortical areas. We begin to address this gap using genetic labeling combined with large vo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01de5f7763005d77629bf5be3086748a
https://doi.org/10.1111/ejn.15092
https://doi.org/10.1111/ejn.15092
Autor:
Narayanan Kasthuri, Pedro Brugarolas, Vandana Sampathkumar, Gregg A. Wildenberg, Gregory S. Karczmar, Sean Foxley
Publikováno v:
Magnetic Resonance in Medicine. 85:667-677
Purpose Dysmyelinating diseases are characterized by abnormal myelin formation and function. Such microstructural abnormalities in myelin have been demonstrated to produce measurable effects on the MR signal. This work examines these effects on measu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78e121929640086527937c8af5b82a2
https://doi.org/10.1002/mrm.28440
https://doi.org/10.1002/mrm.28440