Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Vandana Lamba"'
Autor:
Arvind Rajpal, Mary Huber, Patrick G. Holder, Xiaodi A Deng, Jason M. Hogan, Sanjeev Gangwar, Gavin Dollinger, Xiang Shao, Sayumi Yamazoe, Vandana Lamba, Chetana Rao, Srikanth Kotapati, Pavel Strop, Sean M. West, Cong Qiang
Publikováno v:
Bioconjugate Chemistry. 31:1199-1208
Antibody-drug conjugates (ADCs) are a therapeutic modality that traditionally enable the targeted delivery of highly potent cytotoxic agents to specific cells such as tumor cells. More recently, antibodies have been used to deliver molecules such as
Publikováno v:
Journal of the American Chemical Society. 139:11089-11095
Control of enzyme activity is fundamental to biology and represents a long-term goal in bioengineering and precision therapeutics. While several powerful molecular strategies have been developed, limitations remain in their generalizability and dynam
Publikováno v:
Journal of the American Chemical Society. 138:9902-9909
Proton transfer reactions are ubiquitous in enzymes and utilize active site residues as general acids and bases. Crystal structures and site-directed mutagenesis are routinely used to identify these residues, but assessment of their catalytic contrib
Autor:
Marcello Forconi, Vandana Lamba, Enis Sanchez, Lauren Rose Fanning, Daniel Herschlag, Maria Alejandra Alvarez, Kathryn Howe
Publikováno v:
Biochemistry. 56(4)
Kemp eliminases represent the most successful class of computationally designed enzymes, with rate accelerations up to 109-fold relative to the same reaction in aqueous solution. Nevertheless, several other systems, such as micelles, catalytic antibo
Autor:
Vandana Lamba, Indraneel Ghosh
Publikováno v:
Current pharmaceutical design. 18(20)
Over the past decade, therapeutics that target subsets of the 518 human protein kinases have played a vital role in the fight against cancer. Protein kinases are typically targeted at the adenosine triphosphate (ATP) binding cleft by type I and II in
Autor:
Jason P. Schwans, Daniel Herschlag, Aditya Natarajan, Fanny Sunden, Filip Yabukarski, Vandana Lamba
Publikováno v:
Science. 349:936-936
Fried et al . (Reports, 19 December 2014, p. 1510) demonstrated a strong correlation between reaction rate and the carbonyl stretching frequency of a product analog bound to ketosteroid isomerase oxyanion hole mutants and concluded that the active-si