Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Vanda Pogacic"'
Autor:
Juerg Schwaller, Stefan Knapp, Sandrine Meyer-Monard, Andrea Biondi, Christelle Gasser, Panagis Filippakopoulos, Oleg Fedorov, Alex N. Bullock, Vanda Pogacic
Supplementary Figure 1 from Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0bdb35e928fcf24388acd07b8b81ac
https://doi.org/10.1158/0008-5472.22367984
https://doi.org/10.1158/0008-5472.22367984
Autor:
Juerg Schwaller, Stefan Knapp, Sandrine Meyer-Monard, Andrea Biondi, Christelle Gasser, Panagis Filippakopoulos, Oleg Fedorov, Alex N. Bullock, Vanda Pogacic
Supplementary Table 1 from Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c894b65e42f8081e7f01e99a16e4a4
https://doi.org/10.1158/0008-5472.22367978.v1
https://doi.org/10.1158/0008-5472.22367978.v1
Autor:
Juerg Schwaller, Stefan Knapp, Sandrine Meyer-Monard, Andrea Biondi, Christelle Gasser, Panagis Filippakopoulos, Oleg Fedorov, Alex N. Bullock, Vanda Pogacic
Supplementary Legends from Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b841feeb69084c3d13888dd2cac165a
https://doi.org/10.1158/0008-5472.22367981
https://doi.org/10.1158/0008-5472.22367981
Autor:
Juerg Schwaller, Stefan Knapp, Sandrine Meyer-Monard, Andrea Biondi, Christelle Gasser, Panagis Filippakopoulos, Oleg Fedorov, Alex N. Bullock, Vanda Pogacic
Much attention has recently been focused on PIM kinases as potential targets for the treatment of hematopoietic malignancies and some solid cancers. Using protein stability shift assays, we identified a family of imidazo[1,2-b]pyridazines to specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6ca27e1243214b78aaa1124a18f116
https://doi.org/10.1158/0008-5472.c.6495761.v1
https://doi.org/10.1158/0008-5472.c.6495761.v1
Autor:
Michael Sundström, Oleg Fedorov, Stefan Knapp, Brian D. Marsden, P. Rellos, Juerg Schwaller, Vanda Pogacic, Alex N. Bullock, Susanne Müller
Publikováno v:
Proceedings of the National Academy of Sciences. 104:20523-20528
Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has been linked to disease development. A large number of kinase inhibitors are therefore currently under investigation in clinical trials, and so far seven inhi
Autor:
Craig B. Thompson, Jan Cools, Justus Duyster, Martijn C. Nawijn, Casey J. Fox, Juerg Schwaller, Marina Bendit, Richard Chappuis, Vanda Pogacic, Myriam Adam
Publikováno v:
Cancer Research, 66(7), 3828-3835. AMER ASSOC CANCER RESEARCH
Previous studies have shown that activation of the signal transducer and activator of transcription 5 (STAT5) plays an essential role in leukemogenesis mediated through constitutive activated protein tyrosine kinases (PTK). Because PIM-1 is a STAT5 t
Autor:
Vanda Pogacic, Witold Filipowicz
Publikováno v:
Current Opinion in Cell Biology. 14:319-327
Eukaryotic cells contain a very complex population of small nucleolar RNAs. They function, as small nucleolar ribonucleoproteins, in pre-ribosomal RNA processing reactions, and also guide methylation and pseudouridylation of ribosomal RNA, spliceosom
Publikováno v:
Molecular and Cellular Biology. 20:9028-9040
The H/ACA small nucleolar RNAs (snoRNAs) are involved in pseudouridylation of pre-rRNAs. In the yeast Saccharomyces cerevisiae, four common proteins are associated with H/ACA snoRNAs: Gar1p, Cbf5p, Nhp2p, and Nop10p. In vitro reconstitution studies s
Publikováno v:
Molecular and Cellular Biology. 20:3037-3048
The nucleolus of eukaryotic cells harbors a large population of small nucleolar RNAs (snoRNAs) that play critical roles in pre-rRNA processing and modification (for reviews, see references 43, 63, 64, 67, 71, 74, and 75). Two major classes of snoRNAs
Autor:
Vanda Pogacic Kramp
Publikováno v:
Neuro-degenerative diseases. 9(4)