Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Vancevska A"'
Autor:
Timothy P. Lippert, Paulina Marzec, Aurora I. Idilli, Grzegorz Sarek, Aleksandra Vancevska, Mark Bower, Paul J. Farrell, Päivi M. Ojala, Niklas Feldhahn, Simon J. Boulton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
~15% of cancers induce alternative lengthening of telomeres (ALT) to activate telomere maintenance. Here, the authors reveal that infection with Kaposi’s sarcoma herpesvirus (KSHV) induces acquisition of ALT-like features in previously non-ALT cell
Externí odkaz:
https://doaj.org/article/10dff1fa37054d0fb9e5c512d4b0b3e9
Akademický článek
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Autor:
Alexandra Vancevska, Joachim Lingner, Chih-Yi Gabriela Lin, Anna Christina Naeger, Thomas Lunardi, Gérald Lossaint
Publikováno v:
Nucleic Acids Research
Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90c389a0b2fa0d68eeaf64c741939bb
https://doi.org/10.1093/nar/gkab1015
https://doi.org/10.1093/nar/gkab1015
Autor:
Roopesh Anand, Erika Buechelmaier, Ondrej Belan, Matthew Newton, Aleksandra Vancevska, Artur Kaczmarczyk, Tohru Takaki, David S. Rueda, Simon N. Powell, Simon J. Boulton
Publikováno v:
Nature
DNA double-stranded breaks (DSBs) are deleterious lesions, and their incorrect repair can drive cancer development1. HELQ is a superfamily 2 helicase with 3′ to 5′ polarity, and its disruption in mice confers germ cells loss, infertility and incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097ff54116635846b7903361da64aa48
Autor:
Ondrej Belan, Marie Sebald, Marek Adamowicz, Roopesh Anand, Aleksandra Vancevska, Joana Neves, Vera Grinkevich, Graeme Hewitt, Sandra Segura-Bayona, Roberto Bellelli, Helen M.R. Robinson, Geoff S. Higgins, Graeme C.M. Smith, Stephen C. West, David S. Rueda, Simon J. Boulton
Publikováno v:
Molecular Cell. 82:4664-4680.e9
POLQ is a key effector of DSB repair by microhomology-mediated end-joining (MMEJ) and is overexpressed in many cancers. POLQ inhibitors confer synthetic lethality in HR and Shieldin-deficient cancer cells, which has been proposed to reflect a critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0504a15f604a07e0bec33a46362c6602
https://doi.org/10.1016/j.molcel.2022.11.008
https://doi.org/10.1016/j.molcel.2022.11.008
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Aleksandra Vancevska, David Rueda, Simon N. Powell, Erika S. Buechelmaier, Matthew D. Newton, Ondrej Belan, Artur Kaczmarczyk, Simon J. Boulton, Roopesh Anand
DNA double strand breaks (DSBs) are deleterious lesions, and their incorrect repair can drive cancer development1. HELQ is a superfamily 2 helicase with 3’ to 5’ polarity, whose disruption in mice confers germ cells loss, infertility and increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99c6ea43e93065f18c0792c23777d0eb
https://doi.org/10.21203/rs.3.rs-583248/v1
https://doi.org/10.21203/rs.3.rs-583248/v1
Autor:
Aurora I. Idilli, Paulina Marzec, Simon J. Boulton, Timothy P. Lippert, Päivi M. Ojala, Mark Bower, Niklas Feldhahn, Aleksandra Vancevska, Grzegorz Sarek, Paul J. Farrell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
To achieve replicative immortality, cancer cells must activate telomere maintenance mechanisms to prevent telomere shortening. ~85% of cancers circumvent telomeric attrition by re-expressing telomerase, while the remaining ~15% of cancers induce alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13118b17fbec44795c78b9b81823ee4e
https://doi.org/10.1038/s41467-020-20819-4
https://doi.org/10.1038/s41467-020-20819-4
Autor:
Sebastian Deindl, Christopher D.O. Cooper, Lucia Sommerova, Ellie Herbert, Harshil Patel, Antonia Tomás-Loba, Stephen J. Pettitt, Ivan Ahel, Tohru Takaki, Robert J. Goldstone, Gordon Stamp, Kasper Fugger, Phil Ruis, Stephen C. West, Rachel Brough, Roberto Bellelli, Dragana Ahel, Christopher J. Lord, Graeme Hewitt, Laura C. Lehmann, Valerie Borel, J. Ross Chapman, Kang Zhu, Aleksandra Vancevska, Simon J. Boulton, Deborah Schneider-Luftman, Sandra Segura-Bayona
Publikováno v:
Molecular Cell
Repisalud
Instituto de Salud Carlos III (ISCIII)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Summary Chromatin is a barrier to efficient DNA repair, as it hinders access and processing of certain DNA lesions. ALC1/CHD1L is a nucleosome-remodeling enzyme that responds to DNA damage, but its precise function in DNA repair remains unknown. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2174f57c21d002678255af3abeae011
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430412
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430412