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of 202
pro vyhledávání: '"Vance G. Nielsen"'
Autor:
Vance G. Nielsen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6334 (2024)
Eastern Diamondback Rattlesnake (Crotalus adamanteus) envenomation is a medical emergency encountered in the Southeastern United States. The venom contains a snake venom thrombin-like enzyme (SVTLE) that is defibrinogenating, causing coagulopathy wit
Externí odkaz:
https://doaj.org/article/01dddb4e27b244ce9c92f5b71de7c6a6
Autor:
Vance G. Nielsen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6426 (2024)
Ruthenium chloride (RuCl3) is widely utilized for synthesis and catalysis of numerous compounds in academia and industry and is utilized as a key molecule in a variety of compounds with medical applications. Interestingly, RuCl3 has been demonstrated
Externí odkaz:
https://doaj.org/article/b30fc23cfa5b4b729bf93bfdb84fe7c0
Autor:
Vance G. Nielsen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13939 (2023)
Venomous snake bite adversely affects millions of people yearly, but few animal models allow for the determination of toxicodynamic timelines with hemotoxic venoms to characterize the onset and severity of coagulopathy or assess novel, site-directed
Externí odkaz:
https://doaj.org/article/fa191df17f204c10be41db7ca458b627
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3302 (2023)
The processes of blood coagulation and fibrinolysis that in part maintain the physical integrity of the circulatory system and fluidity of its contents are complex as they are critical for life. While the roles played by cellular components and circu
Externí odkaz:
https://doaj.org/article/3a6a1dd2b39c45f1a4431e1e5eb56d90
Autor:
Toshinobu Kazui, Vance G. Nielsen, Spencer D. Audie, Rajagopalan M. Venkataramani, John T. Bryant, Kristin Swenson, Paul M. Ford
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 9, Iss 4, p 118 (2022)
Severe congenital Factor XI (FXI) deficiency (
Externí odkaz:
https://doaj.org/article/a35918545a1f42c3a53b049a6edaddaf
Autor:
Vance G. Nielsen, Michael T. Wagner
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2128 (2022)
Pain—acute, chronic and debilitating—is the most feared neurotoxicity resulting from a survivable venomous snake bite. The purpose of this review is to present in a novel paradigm what we know about the molecular mechanisms responsible for pain a
Externí odkaz:
https://doaj.org/article/a8fd0aff4a6b47cdbdd7058c35e8fe5b
Autor:
Vance G. Nielsen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4612 (2021)
Procoagulant snake venoms have been inhibited by the ruthenium containing compounds CORM-2 and RuCl3 separately, presumably by interacting with critical histidine or other sulfur-containing amino acids on key venom enzymes. However, combinations of t
Externí odkaz:
https://doaj.org/article/9f96deac94954d839d05ee8ce2d8a7cf
Autor:
Vance G. Nielsen
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 2970 (2020)
The demonstration that carbon monoxide releasing molecules (CORMs) affect experimental systems by the release of carbon monoxide, and not via the interaction of the inactivated CORM, has been an accepted paradigm for decades. However, it has recently
Externí odkaz:
https://doaj.org/article/ba133ef4675f4f98b2576df26effa858
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2082 (2020)
Using thrombelastography to gain mechanistic insights, recent investigations have identified enzymes and compounds in Naja and Crotalus species’ neurotoxic venoms that are anticoagulant in nature. The neurotoxic venoms of the four extant species of
Externí odkaz:
https://doaj.org/article/e19cb705c97e49edaaf0848ac11c7646
Autor:
Vance G. Nielsen
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4853 (2019)
Snake venom enzymes of the L-amino acid oxidase (LAAO) class are responsible for tissue hemorrhage, edema, and derangement of platelet function. However, what role, if any, these flavoenzymes play in altering plasmatic coagulation have not been well
Externí odkaz:
https://doaj.org/article/3ae6de92a355485092cc2180aec13859