Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy

Autor: Giuseppe Campiani, Tuhina Khan, Cristina Ulivieri, Leopoldo Staiano, Chiara Papulino, Stefania Magnano, Seema Nathwani, Anna Ramunno, Daniel Lucena-Agell, Nicola Relitti, Stefano Federico, Luca Pozzetti, Gabriele Carullo, Alice Casagni, Simone Brogi, Francesca Vanni, Paola Galatello, Magda Ghanim, Niamh McCabe, Stefania Lamponi, Massimo Valoti, Ola Ibrahim, Jeffrey O'Sullivan, Richard Turkington, Vincent P. Kelly, Ruben VanWemmel, J. Fernando Díaz, Sandra Gemma, Daniela Zisterer, Lucia Altucci, Maria Antonietta De Matteis, Stefania Butini, Rosaria Benedetti

Publikováno v: Campiani, G, Khan, T, Ulivieri, C, Staiano, L, Papulino, C, Magnano, S, Nathwani, S, Ramunno, A, Lucena-Agell, D, Relitti, N, Federico, S, Pozzetti, L, Carullo, G, Casagni, A, Brogi, S, Vanni, F, Galatello, P, Ghanim, M, McCabe, N, Lamponi, S, Valoti, M, Ibrahim, O, O'Sullivan, J, Turkington, R, Kelly, V P, VanWemmel, R, Díaz, J F, Gemma, S, Zisterer, D, Altucci, L, De Matteis, A, Butini, S & Benedetti, R 2022, ' Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy ', European journal of medicinal chemistry . https://doi.org/10.1016/j.ejmech.2022.114274
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96 p.-20 fig.-7 tab.
Autophagy is a lysosome dependent cell survival mechanism and is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Targeting autophagy in cancer therapy attracted conside

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http://hdl.handle.net/11386/4802551