Accessible chromatin maps of inflammatory bowel disease intestine nominate cell-type mediators of genetic disease risk.

Autor: Wayman JA, Yang Z, Angerman E, Bonkowski E, Jurickova I, Chen X, Bejjani AT, Parks L, Parameswaran S, Miethke AG, VanDussen KL, Dhaliwal J, Weirauch MT, Kottyan LC, Denson LA, Miraldi ER

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 13. Date of Electronic Publication: 2024 Feb 13.

Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn's disease, and celiac disease.

Autor: Braun T; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel., Sosnovski KE; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Amir A; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel., BenShoshan M; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., VanDussen KL; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Karns R; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Levhar N; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Abbas-Egbariya H; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Hadar R; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel., Efroni G; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel., Castel D; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel., Avivi C; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel., Rosen MJ; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Center for Pediatric IBD and Celiac Disease, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA., Grifiths AM; Hospital for Sick Children, Toronto, Canada., Walters TD; Hospital for Sick Children, Toronto, Canada., Mack DR; Children's Hospital of East Ontario, Ottawa, Ontario, Canada., Boyle BM; Nationwide Children's Hospital, Columbus, Ohio, USA., Ali SA; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan., Moore SR; Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA., Schirmer M; The Technical University of Munich, Munich, Germany., Xavier RJ; Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA.; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Kugathasan S; Emory University, Atlanta, Georgia, USA., Jegga AG; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Department of Computer Science, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Engineering, Cincinnati, Ohio, USA., Weiss B; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Mayer C; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Barshack I; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Ben-Horin S; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Ulitsky I; Departments of Biological Regulation and Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Beucher A; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom., Ferrer J; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.; Regulatory Genomics and Diabetes, Centre for Genomic Regulation, the Barcelona Institute of Science and Technology, Barcelona, Spain.; Centro de Investigación Biomédica en red Diabetes y enfermedades metabólicas asociadas (CIBERDEM), Spain., Hyams JS; Connecticut Children's Medical Center, Hartford, Connecticut, USA., Denson LA; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Haberman Y; Sheba Medical Center, Tel-Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Publikováno v: JCI insight [JCI Insight] 2023 Jul 24; Vol. 8 (14). Date of Electronic Publication: 2023 Jul 24.

IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation.

Autor: Overcast GR; Immunology Graduate Program, University of Texas Southwestern Medical Center at Dallas , Dallas, TX, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA., Meibers HE; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center , University of Cincinnati, Cincinnati, OH, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA., Eshleman EM; Division of Immunobiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA., Saha I; Division of Immunobiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA., Waggoner L; Division of Immunobiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA., Patel KN; Divisions of Gastroenterology, Hepatology, and Nutrition and of Developmental Biology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA., Jain VG; Division of Neonatology, University of Alabama at Birmingham , Birmingham, AL, USA., Haslam DB; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati , Cincinnati, OH, USA., Alenghat T; Division of Immunobiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati , Cincinnati, OH, USA., VanDussen KL; Divisions of Gastroenterology, Hepatology, and Nutrition and of Developmental Biology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati , Cincinnati, OH, USA., Pasare C; Division of Immunobiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati , Cincinnati, OH, USA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2023 Jun 05; Vol. 220 (6). Date of Electronic Publication: 2023 Mar 28.

Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity.

Autor: Strine MS; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA., Alfajaro MM; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA., Graziano VR; Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA., Song J; Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA., Hsieh LL; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA., Hill R; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Guo J; Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA., VanDussen KL; Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA., Orchard RC; Department of Immunology, University of Texas Southwestern Medical School, Dallas, TX, USA., Baldridge MT; Department of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, Saint Louis, MO, USA., Lee S; Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA. Electronic address: sanghyun_lee@brown.edu., Wilen CB; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA. Electronic address: craig.wilen@yale.edu.

Publikováno v: Cell reports [Cell Rep] 2022 Nov 08; Vol. 41 (6), pp. 111593.

Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation.

Autor: Liu TC; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: ta-chiang.liu@wustl.edu., Kern JT; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Jain U; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Sonnek NM; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Xiong S; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Simpson KF; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., VanDussen KL; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Winkler ES; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Haritunians T; The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles 90048, USA., Malique A; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Lu Q; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Sasaki Y; Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA., Storer C; Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA., Diamond MS; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Head RD; Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA., McGovern DPB; The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles 90048, USA., Stappenbeck TS; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: stappet@ccf.org.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2021 Jun 09; Vol. 29 (6), pp. 988-1001.e6. Date of Electronic Publication: 2021 May 18.