Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach.

Autor: Mahoney SA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States., VanDongen NS; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States., Greenberg NT; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States., Venkatasubramanian R; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States., Rossman MJ; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States., Widlansky ME; Department of Medicine and Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States., Brunt VE; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States.; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States., Bernaldo de Quirós Y; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States.; Institute of Animal Health and Food Safety, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain., Seals DR; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States., Clayton ZS; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States.

Publikováno v: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2024 May 01; Vol. 326 (5), pp. H1279-H1290. Date of Electronic Publication: 2024 Mar 22.

Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment.

Autor: Clayton ZS; Department of Integrative Physiology, University of Colorado Boulder (Z.S.C., M.J.R., S.A.M., R.V., G.S.M., D.A.H., N.S.V., N.T.G., A.G.L., K.R.L., V.E.B., D.R.S.)., Rossman MJ; Department of Integrative Physiology, University of Colorado Boulder (Z.S.C., M.J.R., S.A.M., R.V., G.S.M., D.A.H., N.S.V., N.T.G., A.G.L., K.R.L., V.E.B., D.R.S.)., Mahoney SA; Department of Integrative Physiology, University of Colorado Boulder (Z.S.C., M.J.R., S.A.M., R.V., G.S.M., D.A.H., N.S.V., N.T.G., A.G.L., K.R.L., V.E.B., D.R.S.)., Venkatasubramanian R; Department of Integrative Physiology, University of Colorado Boulder (Z.S.C., M.J.R., S.A.M., R.V., G.S.M., D.A.H., N.S.V., N.T.G., A.G.L., K.R.L., V.E.B., D.R.S.)., Maurer GS; Department of Integrative Physiology, University of Colorado Boulder (Z.S.C., M.J.R., S.A.M., R.V., G.S.M., D.A.H., N.S.V., N.T.G., A.G.L., K.R.L., V.E.B., D.R.S.)., Hutton DA; Department of Integrative Physiology, University of Colorado Boulder (Z.S.C., M.J.R., S.A.M., R.V., G.S.M., D.A.H., N.S.V., N.T.G., A.G.L., K.R.L., V.E.B., D.R.S.)., VanDongen NS; Department of Integrative Physiology, University of Colorado Boulder (Z.S.C., M.J.R., S.A.M., R.V., G.S.M., D.A.H., N.S.V., N.T.G., A.G.L., K.R.L., V.E.B., D.R.S.)., Greenberg NT; Department of Integrative Physiology, University of Colorado Boulder (Z.S.C., M.J.R., S.A.M., R.V., G.S.M., D.A.H., N.S.V., N.T.G., A.G.L., K.R.L., V.E.B., D.R.S.)., Longtine AG; Department of Integrative Physiology, University of Colorado Boulder (Z.S.C., M.J.R., S.A.M., R.V., G.S.M., D.A.H., N.S.V., N.T.G., A.G.L., K.R.L., V.E.B., D.R.S.)., Ludwig KR; Department of Integrative Physiology, University of Colorado Boulder (Z.S.C., M.J.R., S.A.M., R.V., G.S.M., D.A.H., N.S.V., N.T.G., A.G.L., K.R.L., V.E.B., D.R.S.)., Brunt VE; Department of Integrative Physiology, University of Colorado Boulder (Z.S.C., M.J.R., S.A.M., R.V., G.S.M., D.A.H., N.S.V., N.T.G., A.G.L., K.R.L., V.E.B., D.R.S.)., LaRocca TJ; Department of Health & Exercise Science (T.J.L.), Colorado State University, Fort Collins.; Center for Healthy Aging (T.J.L.), Colorado State University, Fort Collins., Campisi J; The Buck Institute for Research on Aging, Novato, CA (J.C., S.M.).; Lawrence Berkeley National Laboratory, Berkeley, CA (J.C.)., Melov S; The Buck Institute for Research on Aging, Novato, CA (J.C., S.M.)., Seals DR; Department of Integrative Physiology, University of Colorado Boulder (Z.S.C., M.J.R., S.A.M., R.V., G.S.M., D.A.H., N.S.V., N.T.G., A.G.L., K.R.L., V.E.B., D.R.S.).

Publikováno v: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2023 Oct; Vol. 80 (10), pp. 2072-2087. Date of Electronic Publication: 2023 Aug 18.

Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice.

Autor: Casso AG; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., VanDongen NS; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Gioscia-Ryan RA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Clayton ZS; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Greenberg NT; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Ziemba BP; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Hutton DA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Neilson AP; Department of Food Science and Technology, Virginia Tech, Blacksburg, Virginia, USA., Davy KP; Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia, USA., Seals DR; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Brunt VE; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Publikováno v: The Journal of physiology [J Physiol] 2022 Nov; Vol. 600 (21), pp. 4633-4651. Date of Electronic Publication: 2022 Oct 13.

Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans.

Autor: Brunt VE; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.)., Casso AG; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.)., Gioscia-Ryan RA; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.)., Sapinsley ZJ; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.)., Ziemba BP; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.)., Clayton ZS; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.)., Bazzoni AE; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.)., VanDongen NS; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.)., Richey JJ; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.)., Hutton DA; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.)., Zigler MC; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.)., Neilson AP; Department of Food Science and Technology (A.P.N.).; Now with Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis (A.P.N.)., Davy KP; Department of Human Nutrition, Foods, and Exercise (K.P.D.), Virginia Tech, Blacksburg., Seals DR; From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).

Publikováno v: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2021 Aug; Vol. 78 (2), pp. 499-511. Date of Electronic Publication: 2021 May 10.

Lifelong voluntary aerobic exercise prevents age- and Western diet- induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice.

Autor: Gioscia-Ryan RA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Clayton ZS; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Zigler MC; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Richey JJ; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Cuevas LM; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Rossman MJ; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Battson ML; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Ziemba BP; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Hutton DA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., VanDongen NS; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Seals DR; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.

Publikováno v: The Journal of physiology [J Physiol] 2021 Feb; Vol. 599 (3), pp. 911-925. Date of Electronic Publication: 2020 Oct 28.