Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development

Autor: Goldring, C., Weaver, R., Kramer, B., Klingmueller, U., Oppelt, A., Van der Water, B., Commandeur, J., Guillouzo, A., Naisbitt, D., French, N., Kitteringham, N., Pridgeon, C., Knolle, P., Sidaway, J., Sison-Young, R., Kamalian, L., Mercer, A., Faulkner, L., Pieters, R., Ingelman-Sundberg, M., Kevin Park, B.

Publikováno v: In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering 2013

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Optimizing drug discovery by Investigative Toxicology: Current and future trends.

Autor: Beilmann M; Nonclinical Drug Safety, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany., Boonen H; H. Lundbeck A/S, Valby, Denmark., Czich A; Sanofi Deutschland GmbH, Frankfurt, Germany., Dear G; Platform Technology & Science, David Jack Centre for R&D, GSK, Hertfordshire, UK., Hewitt P; Non Clinical Safety, Merck KGaA, Darmstadt, Germany., Mow T; Global Discovery and Development Sciences, Novo Nordisk A/S, Maaloev, Denmark., Newham P; Drug Safety and Metabolism, Astra Zeneca, Cambridge, UK., Oinonen T; Investigative Toxicology and ADME, Orion Pharma, Espoo, Finland., Pognan F; PreClinical Safety, Novartis Pharma, Basel, Switzerland., Roth A; Pharma Research and Early Development, Hoffmann-La Roche Ltd, Basel, Switzerland., Valentin JP; Development Science, UCB Biopharma SPRL, Braine-l'Alleud, Belgium., Van Goethem F; Mechanistic & Investigative Toxicology, Discovery Sciences, Janssen Research & Development, Beerse, Belgium., Weaver RJ; Research & Biopharmacy, Servier, Suresnes Cedex, France., Birk B; Experimental Toxicology and Ecology, BASF, Ludwigshafen, Germany., Boyer S; Computational Toxicology, Swedish Toxicological Sciences Research Center, Södertäljje, Sweden., Caloni F; Department of Veterinary Medicine (DIMEVET), Università degli Studi di Milano, Milan, Italy., Chen AE; Organovo, Inc., San Diego, CA, USA., Corvi R; EURL-ECVAM, Joint Research Center, European Commission, Ispra (VA), Italy., Cronin MTD; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, England., Daneshian M; Center for Alternatives to Animal Testing (CAAT)-Europe, University of Konstanz, Konstanz, Germany., Ewart LC; Drug Safety and Metabolism, Astra Zeneca, Cambridge, UK., Fitzgerald RE; Swiss Centre for Applied Human Toxicology, SCAHT / University of Basel, Basel, Switzerland., Hamilton GA; Emulate Inc., Boston, MA, USA., Hartung T; Johns Hopkins University, CAAT, Baltimore, MD, USA.; Center for Alternatives to Animal Testing (CAAT)-Europe, University of Konstanz, Konstanz, Germany., Kangas JD; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA., Kramer NI; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Leist M; Center for Alternatives to Animal Testing (CAAT)-Europe, University of Konstanz, Konstanz, Germany., Marx U; TissUse, GmbH, Berlin Germany., Polak S; Certara UK (Simcyp), Sheffield, United Kingdom.; Jagiellonian University Medical College, Kraków, Poland., Rovida C; Center for Alternatives to Animal Testing (CAAT)-Europe, University of Konstanz, Konstanz, Germany., Testai E; Istituto Superiore di Sanità, Rome, Italy., Van der Water B; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, RA Leiden, The Netherlands., Vulto P; Mimetas, Leiden, The Netherlands., Steger-Hartmann T; Research & Development, Pharmaceuticals, Investigational Toxicology, Bayer AG, Berlin, Germany.

Publikováno v: ALTEX [ALTEX] 2019; Vol. 36 (2), pp. 289-313. Date of Electronic Publication: 2018 Dec 20.