Zobrazeno 1 - 10
of 676
pro vyhledávání: '"Van der Marel GA"'
Publikováno v:
Organic Letters. 3:731-733
The cyclooctenol derivative 1 can be transformed into the nine-membered ring lactone 3, as well as the amino-containing carbocycles 4 and 5. The corresponding ketone 2 gives access to the conformationally locked azasugar 6.
Autor:
van den Berg Rj, van der Marel Ga, Remy E. J. N. Litjens, Herman S. Overkleeft, van den Bos Lj
Publikováno v:
Organic letters. 7(10)
The chemo- and regioselective TEMPO/BAIB-mediated oxidation of 2,6- and 3,6-dihydroxy 1-thio glycopyranosides to the corresponding 1-thio uronic acid lactones is described. These locked 1-thio glycuronides can directly be used as donors in glycosidat
Publikováno v:
Bioconjugate chemistry. 11(6)
This work describes the first automated solid-phase synthesis of metal derivatives of peptide nucleic acid (PNA) oligomers and their interaction with DNA and PNA. PNA constitutes a relatively young and very promising class of DNA analogues with excel
Publikováno v:
Angewandte Chemie (International ed. in English). 39(17)
Autor:
van Boom Jh, Michiel A. Leeuwenburgh, Remy E. J. N. Litjens, van der Marel Ga, Herman S. Overkleeft, Jeroen D. C. Codée
Publikováno v:
Organic letters. 2(9)
[formula: see text] Tributyltin radical mediated cyclization of carbohydrate-derived beta-(alkynyloxy)acrylates leading to highly functionalized cis- and trans-fused bicyclic ethers of various ring sizes is described. The efficacy of the radical cycl
Publikováno v:
Angewandte Chemie (International ed. in English). 39(2)
Cross-linking ability is possible with the oligonucleotide-tethered, monofunctional trans-Pt(II) complex shown. It was synthesized by a novel solid-phase approach comprising conjugation of immobilized tetrathymidylic acid with a trans-a(2)Pt(II) buil
Publikováno v:
Angewandte Chemie (International ed. in English). 39(2)
The introduction of a urea bond linking a protected diethylenetriamine (DETA) unit and the terminal amino group of a resin-bound peptide nucleic acid (PNA) decamer gave access to a PNA - DETA adduct (shown here), which hydrolyzed the target 25-mer RN
Autor:
van den Elst Ha, van der Marel Ga, van Boom Jh, van de Wetering Ki, Stuivenberg Hr, van der Kaaden Jc, Nico J. Meeuwenoord, Geri F. Moolenaar, R. Visse, Monaco, Nora Goosen, Esther E.A. Verhoeven
Publikováno v:
Nucleosidesnucleotides. 18(6-7)
Three new cholesterol-containing phosphoramidites where synthesized and used in automated synthesis of modified DNA fragments. These cholesterol lesions are good substrates for the E. coli UvrABC endonuclease. In vitro they are incised from damaged D
Autor:
van der Marel Ga, van Boom Jh, Guido V. Bloemberg, van Leeuwen S, Lagas Rm, Ben J. J. Lugtenberg, Herman P. Spaink
Publikováno v:
Biochemistry. 34(39)
All lipo-chitin oligosaccharides identified from Rhizobium leguminosarum carry an O-acetyl moiety on C6 of the nonreducing terminal N-acetylglucosamine residue. Previously, we have shown that purified NodL protein, using acetyl-CoA as acetyl donor, i