Non-clinical and first-in-human characterization of ECC5004/AZD5004, a novel once-daily, oral small-molecule GLP-1 receptor agonist.

Autor: Haggag AZ; Anaheim Clinical Trials LLC, Anaheim, California, USA., Xu J; Eccogene Inc., Cambridge, Massachusetts, USA., Butcher L; Eccogene Inc., Cambridge, Massachusetts, USA., Pagnussat S; QPS MRA LLC, Miami, Florida, USA., Davies G; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Lundqvist S; Assays, Profiling and Cell Sciences, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Wang W; Data Sciences and Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Van Zuydam N; Data Sciences and Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Nelander K; Cardiovascular, Renal and Metabolism Biometrics, Late Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Jha A; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gaithersburg, Maryland, USA., Yu H; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gaithersburg, Maryland, USA., Boianelli A; DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Lindmark B; DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Ollerstam A; Cardiovascular, Renal and Metabolism Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Sun X; Eccogene (Shanghai) Co. Ltd., Shanghai, China., Wang F; Eccogene (Shanghai) Co. Ltd., Shanghai, China., Pan X; Eccogene (Shanghai) Co. Ltd., Shanghai, China., Liu H; Eccogene (Shanghai) Co. Ltd., Shanghai, China., Chen W; Eccogene Inc., Cambridge, Massachusetts, USA., Xu J; Eccogene (Shanghai) Co. Ltd., Shanghai, China., Wallenius K; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Zhou J; Eccogene Inc., Cambridge, Massachusetts, USA.

Publikováno v: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2024 Nov 04. Date of Electronic Publication: 2024 Nov 04.

A randomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2.

Autor: Wilkinson T; NIHR Southampton Biomedical Research Centre and University of Southampton, Southampton, UK., De Soyza A; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Carroll M; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Chalmers JD; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Crooks MG; Hull York Medical School, University of Hull, Hull, UK., Griffiths G; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.; University Hospital Southampton NHS Foundation Trust, Southampton, UK., Shankar-Hari M; Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK., Ho LP; Medical Research Council Human Immunology Unit, University of Oxford, Oxford, UK., Horsley A; Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, UK., Kell C; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Lara B; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK., Mishra B; Royal Oldham Hospital, Oldham, UK., Moate R; Early Biometrics, AstraZeneca, Cambridge, UK., Page C; Sackler Institute of Pulmonary Pharmacology, King's College London, London, UK., Pandya H; Clinical Development, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Raw J; Fairfield Hospital, Bury, UK., Reid F; Clinical Development, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Saralaya D; Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK., Scott IC; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Siddiqui S; Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK., Ustianowski A; Regional Infection Unit, North Manchester General Hospital, Manchester, UK., van Zuydam N; Discovery Sciences, AstraZeneca, Gothenburg, Sweden., Woodcock A; Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, UK.; Medicines Evaluation Unit, Manchester University NHS Foundation Trust, Manchester, UK., Singh D; Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, UK.; Medicines Evaluation Unit, Manchester University NHS Foundation Trust, Manchester, UK.

Publikováno v: ERJ open research [ERJ Open Res] 2023 Oct 02; Vol. 9 (5). Date of Electronic Publication: 2023 Oct 02 (Print Publication: 2023).

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

Autor: Mathieson I; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mathi@pennmedicine.upenn.edu., Day FR; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Barban N; Alma Mater Studiorum University of Bologna, Bologna, Italy., Tropf FC; Nuffield College, University of Oxford, Oxford, UK.; École Nationale de la Statistique et de L'administration Économique (ENSAE), Paris, France.; Center for Research in Economics and Statistics (CREST), Paris, France., Brazel DM; Nuffield College, University of Oxford, Oxford, UK.; Leverhulme Centre for Demographic Science, University of Oxford, Oxford, UK., Vaez A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran., van Zuydam N; Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden., Bitarello BD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gardner EJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Akimova ET; Nuffield College, University of Oxford, Oxford, UK.; Leverhulme Centre for Demographic Science, University of Oxford, Oxford, UK., Azad A; DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bergmann S; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa., Bielak LF; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Boomsma DI; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam, the Netherlands., Bosak K; Psychiatric Hospital 'Sveti Ivan', Zagreb, Croatia., Brumat M; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy., Buring JE; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cesarini D; Department of Economics, New York University, New York, NY, USA.; Research Institute for Industrial Economics, Stockholm, Sweden.; National Bureau of Economic Research, Cambridge, MA, USA., Chasman DI; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chavarro JE; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Cocca M; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., Concas MP; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., Davey Smith G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Davies G; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK., Deary IJ; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK., Esko T; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Franco O; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Ganna A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Gaskins AJ; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Gelemanovic A; University of Split School of Medicine, Split, Croatia., de Geus EJC; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Girotto G; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., Gopinath B; Centre for Vision Research, Westmead Institute for Medical Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, Australia., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Gunderson EP; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., He C; Markey Cancer Center, University of Kentucky, Lexington, KY, USA.; Department of Internal Medicine, Division of Medical Oncology, University of Kentucky College of Medicine, Lexington, KY, USA., van Heemst D; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Hill WD; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK., Hoffmann ER; DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany., Hottenga JJ; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Huang H; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Hyppӧnen E; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, Adelaide, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Jansen R; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands., Johannesson M; Department of Economics, Stockholm School of Economics, Stockholm, Sweden., Kamali Z; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran., Kardia SLR; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Kavousi M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Kifley A; Centre for Vision Research, Westmead Institute for Medical Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, Australia., Kiiskinen T; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; National Institute for Health and Welfare, Helsinki, Finland., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Kühnel B; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Liew G; Centre for Vision Research, Westmead Institute for Medical Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, Australia., Lind PA; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Martin NG; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Mbarek H; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Qatar Genome Programme, Qatar Foundation Research, Development and Innovation, Qatar Foundation, Doha, Qatar., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., McMahon G; School of Social and Community Medicine, University of Bristol, Bristol, UK., Medland SE; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Missmer SA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Division of Adolescent and Young Adult Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA., Mitchell P; Centre for Vision Research, Westmead Institute for Medical Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, Australia., Møllegaard S; Department of Sociology, University of Copenhagen, Copenhagen, Denmark., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., Morgan A; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Nauck M; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Penninx BWJH; Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam, the Netherlands., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Peyser PA; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Polašek O; University of Split School of Medicine, Split, Croatia.; Algebra University College, Zagreb, Croatia., Power C; Population, Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK., Pribisalic A; University of Split School of Medicine, Split, Croatia., Redmond P; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK., Rich-Edwards JW; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Women's Health, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Ridker PM; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Rietveld CA; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.; Department of Applied Economics, Erasmus School of Economics, Rotterdam, the Netherlands., Ring SM; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Rose LM; Brigham and Women's Hospital, Boston, MA, USA., Rueedi R; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Shukla V; DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Stankovic S; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Stefánsson K; deCODE Genetics/Amgen Inc., Reykjavik, Iceland., Stöckl D; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Strauch K; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany., Swertz MA; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Thorleifsson G; deCODE Genetics/Amgen Inc., Reykjavik, Iceland., Thorsteinsdottir U; deCODE Genetics/Amgen Inc., Reykjavik, Iceland., Thurik AR; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.; Department of Applied Economics, Erasmus School of Economics, Rotterdam, the Netherlands.; Montpellier Business School, Montpellier, France., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Turman C; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Uitterlinden AG; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Willemsen G; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Zhao JH; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Zhao Y; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., den Hoed M; Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden., Ong KK; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Mills MC; Nuffield College, University of Oxford, Oxford, UK. melinda.mills@nuffield.ox.ac.uk.; Leverhulme Centre for Demographic Science, University of Oxford, Oxford, UK. melinda.mills@nuffield.ox.ac.uk.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. melinda.mills@nuffield.ox.ac.uk.; Department of Economics, Econometrics and Finance, University of Groningen, Groningen, the Netherlands. melinda.mills@nuffield.ox.ac.uk., Perry JRB; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. john.perry@mrc-epid.cam.ac.uk.

Publikováno v: Nature human behaviour [Nat Hum Behav] 2023 May; Vol. 7 (5), pp. 790-801. Date of Electronic Publication: 2023 Mar 02.

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Autor: Ahmad Vaez, Felix R. Day, Iain Mathieson, Harold Snieder, Bárbara Domingues Bitarello, Melinda Mills, van Zuydam N, Nicola Barban, Ken K. Ong, den Hoed M, Perry, Felix C. Tropf, David M. Brazel

Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and also identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identify 43 genomic loci associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6642a5ba2c85a64e4e82d31e321edede
https://doi.org/10.1101/2020.05.19.104455

Evaluation in pig of an intestinal administration device for oral peptide delivery.

Autor: Berg S; The Swedish Drug Delivery Center, Department of Pharmacy, Uppsala University, BMC P.O. Box 580, SE-751 23 Uppsala, Sweden; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Uggla T; Animal Sciences and Technologies, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Antonsson M; Animal Sciences and Technologies, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Nunes SF; Animal Sciences and Technologies, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Englund M; Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Rosengren L; Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Fahraj M; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Wu X; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Govender R; Oral Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca Gothenburg, Sweden., Söderberg M; Cardiovascular, Renal and Metabolism Safety, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Janzén D; Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Van Zuydam N; Data Science and Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Hugerth A; Ferring Pharmaceuticals A/S, Product Development and Drug Delivery, Global Pharmaceutical R&D, Amager Strandvej 405, 2770 Kastrup, Denmark., Larsson A; Applied Chemistry, Department of Chemistry and Chemical Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden., Abrahmsén-Alami S; Innovation Strategies & External Liasons, Pharmaceutical Technology & Development, Operations, AstraZeneca Gothenburg, Sweden., Abrahamsson B; Oral Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca Gothenburg, Sweden., Davies N; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Bergström CAS; The Swedish Drug Delivery Center, Department of Pharmacy, Uppsala University, BMC P.O. Box 580, SE-751 23 Uppsala, Sweden. Electronic address: christel.bergstrom@farmaci.uu.se.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2023 Jan; Vol. 353, pp. 792-801. Date of Electronic Publication: 2022 Dec 16.