IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling

Autor: Maity, Palash C., Bilal, Mayas, Koning, Marvyn T., Young, Marc, van Bergen, Cornelis A. M., Renna, Valerio, Nicolò, Antonella, Datta, Moumita, Gentner-Göbel, Eva, Barendse, Rob S., Somers, Sebastiaan F., de Groen, Ruben A. L., Vermaat, Joost S. P., Steinbrecher, Daniela, Schneider, Christof, Tausch, Eugen, Bittolo, Tamara, Bomben, Riccardo, Mazzarello, Andrea Nicola, del Poeta, Giovanni, Kroes, Wilma G. M., van Wezel, J. Tom, Imkeller, Katharina, Busse, Christian E., Degano, Massimo, Bakchoul, Tamam, Schulz, Axel Ronald, Mei, Henrik, Ghia, Paolo, Kotta, Konstantia, Stamatopoulos, Kostas, Wardemann, Hedda, Zucchetto, Antonella, Chiorazzi, Nicholas, Gattei, Valter, Stilgenbauer, Stephan, Veelken, Hendrik, Jumaa, Hassan

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2020 Feb . 117(8), 4320-4327.

Externí odkaz: https://www.jstor.org/stable/26929087

IGLV3-21*01 is an inherited risk factor for CLL throughthe acquisition of a single-point mutation enablingautonomous BCR signaling

Autor: Maity, Palash C., Bilal, Mayas, Koning, Marvyn T., Young, Marc, Van Bergen, Cornelis A. M., Renna, Valerio, Nicolo, Antonella, Datta, Moumita, Gentner-Göbel, Eva, Barendse, Rob S., Somers, Sebastiaan F., De Groen, Ruben A. L., Vermaat, Joost S. P., Steinbrecher, Daniela, Schneider, Christof, Tausch, Eugen, Bittolo, Tamara, Bomben, Riccardo, Mazzarello, Andrea Nicola, Del Poeta, Giovanni, Kroes, Wilma G. M., Van Wezel, J. Tom, Imkeller, Katharina, Busse, Christian E., Degano, Massimo, Bakchoul, Tamam, Schulz, Axel Ronald, Mei, Henrik, Ghia, Paolo, Kotta, Konstantia, Stamatopoulos, Kostas, Wardemann, Hedda, Zucchetto, Antonella, Chiorazzi, Nicholas, Gattei, Valter, Stilgenbauer, Stephan, Veelken, Hendrik, Jumaa, Hassan

The prognosis of chronic lymphocytic leukemia (CLL) depends on different markers, including cytogenetic aberrations, oncogenic mutations, and mutational status of the immunoglobulin (Ig) heavy-chain variable (IGHV) gene. The number of IGHV mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca16bb4d763543797aeca1e4533daf65

IGLV3-21 * 01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling.

Autor: Maity PC; Institute of Immunology, Ulm University, 89081 Ulm, Germany., Bilal M; Institute of Immunology, Ulm University, 89081 Ulm, Germany., Koning MT; Department of Hematology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Young M; Institute of Immunology, Ulm University, 89081 Ulm, Germany., van Bergen CAM; Department of Hematology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Renna V; Institute of Immunology, Ulm University, 89081 Ulm, Germany., Nicolò A; Institute of Immunology, Ulm University, 89081 Ulm, Germany., Datta M; Institute of Immunology, Ulm University, 89081 Ulm, Germany., Gentner-Göbel E; Institute of Immunology, Ulm University, 89081 Ulm, Germany., Barendse RS; Department of Hematology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Somers SF; Department of Hematology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., de Groen RAL; Department of Hematology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Vermaat JSP; Department of Hematology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Steinbrecher D; Department of Internal Medicine III, Ulm University Hospital, 89081 Ulm, Germany., Schneider C; Department of Internal Medicine III, Ulm University Hospital, 89081 Ulm, Germany., Tausch E; Department of Internal Medicine III, Ulm University Hospital, 89081 Ulm, Germany., Bittolo T; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 33081 Aviano, Italy., Bomben R; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 33081 Aviano, Italy., Mazzarello AN; Karches Center for Oncology Research, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY 11030., Del Poeta G; Division of Hematology, S. Eugenio Hospital and University of Tor Vergata, 00144 Rome, Italy., Kroes WGM; Department of Clinical Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., van Wezel JT; Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Imkeller K; B Cell Immunology, German Cancer Research Center, 69120 Heidelberg, Germany., Busse CE; B Cell Immunology, German Cancer Research Center, 69120 Heidelberg, Germany., Degano M; Biocrystallography Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Bakchoul T; Transfusion Medicine, Medical Faculty of Tübingen and Center for Clinical Transfusion Medicine, Universitätsklinikum Tübingen, 72076 Tübingen, Germany., Schulz AR; Mass Cytometry Lab, German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany., Mei H; Mass Cytometry Lab, German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany., Ghia P; Division of Experimental Oncology, Università Vita-Salute San Raffaele, 20132 Milan, Italy., Kotta K; Institute of Applied Biosciences, Centre for Research and Technology Hellas, 57001 Thessaloniki, Greece., Stamatopoulos K; Institute of Applied Biosciences, Centre for Research and Technology Hellas, 57001 Thessaloniki, Greece., Wardemann H; B Cell Immunology, German Cancer Research Center, 69120 Heidelberg, Germany., Zucchetto A; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 33081 Aviano, Italy., Chiorazzi N; Karches Center for Oncology Research, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY 11030., Gattei V; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 33081 Aviano, Italy., Stilgenbauer S; Department of Internal Medicine III, Ulm University Hospital, 89081 Ulm, Germany.; Department of Hematology, Oncology, Clinical Immunology, and Rheumatology, Saarland University Medical School, 66421 Homburg/Saar, Germany.; José Carreras Institute for Immunology and Gene Therapy, Saarland University Medical School, 66421 Homburg/Saar, Germany., Veelken H; Department of Hematology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Jumaa H; Institute of Immunology, Ulm University, 89081 Ulm, Germany; hassan.jumaa@uni-ulm.de.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 25; Vol. 117 (8), pp. 4320-4327. Date of Electronic Publication: 2020 Feb 11.