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Bacterial ABC multidrug exporters: From shared proteins motifs and features to diversity in molecular mechanisms

Autor: Van Veen, HW

Bacterial ATP-binding cassette (ABC) exporters embrace an enormous range of biological processes. They can mediate the efflux of a wide variety of substrate ranging from small inorganic ions, drugs and antibiotics to large protein toxins and other ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd1c81373f81f49404fa800b434f7b06

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Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions

Autor: Nair, AV, Singh, H, Raturi, S, Neuberger, A, Tong, Z, Ding, N, Agboh, K, van Veen, HW

Publikováno v: Scientific Reports

The expression of polyspecific membrane transporters is one important mechanism by which cells can obtain resistance to structurally different antibiotics and cytotoxic agents. These transporters reduce intracellular drug concentrations to subtoxic l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78a8bc7313f68f0fbb6666e46c4d68e
https://pubmed.ncbi.nlm.nih.gov/27917857

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Probing the ATP Hydrolysis Cycle of the ABC Multidrug Transporter LmrA by Pulsed EPR Spectroscopy

Autor: Clemens Glaubitz, Thomas F. Prisner, Sevdalina Lyubenova, Ute A. Hellmich, Kaltenborn E, van Veen Hw, Rupak Doshi

Publikováno v: Journal of the American Chemical Society. 134:5857-5862

Members of the ATP binding cassette (ABC) transporter superfamily translocate various types of molecules across the membrane at the expense of ATP. This requires cycling through a number of catalytic states. Here, we report conformational changes thr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6e580888aad064331e162f8cf9e8a2
https://doi.org/10.1021/ja211007t

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S-Decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1)

Autor: Cool, RH, Veenstra, MK, van Klompenburg, W, Heyne, RIR, Muller, M, de Vries, EGE, van Veen, HW, Konings, WN

Publikováno v: European Journal of Biochemistry, 269(14), 3470-3478. Blackwell Publishing Ltd

The human multidrug resistance-associated protein(MRP1) is an ATP-dependent efflux pump that transports anionic conjugates, and hydrophobic compounds in a glutathione dependent manner. Similar to the other, well-characterized multidrug transporter P-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::abae585bd21aecda96536d41a6cb35a9
https://research.rug.nl/en/publications/44e76194-a3d3-4090-b7a4-162864394b21

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Structure and dynamics of the membrane-embedded domain of LmrA investigated by coupling polarized ATR-FTIR spectroscopy and H-1/H-2 exchange

Autor: Grimard, [No Value], Vigano, C, Margolles, A, Wattiez, R, van Veen, HW, Konings, WN, Ruysschaert, JM, Goormaghtigh, E

Publikováno v: Biochemistry, 40(39), 11876-11886. AMER CHEMICAL SOC

Bacterial LmrA, an integral membrane protein of Lactococcus lactis, confers multidrug resistance by mediating active extrusion of a wide variety of structurally unrelated compounds. Similar to its eucaryotic homologue P-gp, this protein is a member o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::0216e4c67bcc237fa03bc75e9a4aad36
https://research.rug.nl/en/publications/26f3a78f-a69b-451e-8eb9-5559c2890643

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Activation by gene amplification of pitB, encoding a third phosphate transporter of Escherichia coli K-12

Autor: Hoffer, SM, Schoondermark, P, van Veen, HW, Tommassen, J

Publikováno v: Journal of Bacteriology, 183(15), 4659-4663. AMER SOC MICROBIOLOGY

Two systems for the uptake of inorganic phosphate (P-i) in Escherichia coli, PitA and Pst, have been described. A revertant of a pitA pstS double mutant that could grow on P-i was isolated. We demonstrate that the expression of a new P-i transporter,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::dee4acd7d151b186326e10c8abde0a92
https://research.rug.nl/en/publications/225b6d26-0697-420d-a4c3-2a7f87ccc835

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Cholic acid is accumulated spontaneously, driven by membrane Delta pH, in many lactobacilli

Autor: Kurdi, P, van Veen, HW, Tanaka, H, Mierau, [No Value], Konings, WN, Tannock, GW, Tomita, F, Yokota, A

Publikováno v: Journal of Bacteriology, 182(22), 6525-6528. AMER SOC MICROBIOLOGY

Many lactobacilli from various origins were found to apparently lack cholic acid extrusion activity. Cholic acid was accumulated spontaneously, driven by the transmembrane proton gradient. Accumulation is a newly identified kind of interaction betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::b159cd8729447aa3fea0f12cf66e7b5b
https://research.rug.nl/en/publications/f4f3ff0e-abdd-4b66-9ea9-556024c662b3

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Cholate resistance in Lactococcus lactis is mediated by an ATP-dependent multispecific organic anion transporter

Autor: Yokota, A, Veenstra, M, Kurdi, P, van Veen, HW, Konings, WN

Publikováno v: Journal of Bacteriology, 182(18), 5196-5201. AMER SOC MICROBIOLOGY

The cholate-resistant Lactococcus lactis strain C41-2, derived from mild-type L. lactis MG1363 through selection for growth on cholate-containing medium, displayed a reduced accumulation of cholate due to an enhanced active efflux, However, L. lactis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::5595b996a8de8f17ede2916a65ba6fc4
https://research.rug.nl/en/publications/efe7572b-0215-418e-8772-ba22e3232bf5

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