Výsledky vyhledávání - "Van R. Irion"

Stability of mRNA/cationic lipid lipoplexes in human and rat cerebrospinal fluid: methods and evidence for nonviral mRNA gene delivery to the central nervous system

Autor: Dua M. Anderson, Leon L. Hall, Van R. Irion, James G. Hecker, Anitha R. Ayyalapu, Michael H. Nantz

Publikováno v: Human gene therapy. 14(3)

Clinical applications of gene therapy require advances in gene delivery systems. Although numerous clinical trials are already underway, the ultimate success of gene therapies will depend on gene transfer vectors that facilitate the expression of a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2feb333827c0a286e5c5ccb3bc834346
https://pubmed.ncbi.nlm.nih.gov/12639300

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Nonviral gene delivery to the lateral ventricles in rat brain: initial evidence for widespread distribution and expression in the central nervous system

Autor: James G Hecker, Van R. Irion, Leon L. Hall

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 3(3)

The use of DNA for nonviral gene expression depends on several factors. These include (i) delivery and accessibility to the targeted tissue, (ii) protection from extracellular degradation, (iii) sufficient uptake by cells of interest, and (iv) protec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0182e37eaea8a8cc028369d4402c29d
https://pubmed.ncbi.nlm.nih.gov/11273780

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Room E, 10/16/2000 2: 00 PM - 4: 00 PM (PS) Non-Viral mRNA and DNA Gene Delivery to Rat Brain for Transient, Peri-Operative Gene Expression

Autor: James G. Hecker, Van R. Irion

Publikováno v: Anesthesiology. 93:A-723

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bdb6e80a552b08b9a9f8fda3e973321
https://doi.org/10.1097/00000542-200009001-00723

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