Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers

Autor: Tom Van Nyen, Mélanie Planque, Lilian van Wagensveld, Joao A. G. Duarte, Esther A. Zaal, Ali Talebi, Matteo Rossi, Pierre-René Körner, Lara Rizzotto, Stijn Moens, Wout De Wispelaere, Regina E. M. Baiden-Amissah, Gabe S. Sonke, Hugo M. Horlings, Guy Eelen, Emanuele Berardi, Johannes V. Swinnen, Celia R. Berkers, Peter Carmeliet, Diether Lambrechts, Ben Davidson, Reuven Agami, Sarah-Maria Fendt, Daniela Annibali, Frédéric Amant

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Metabolic reprogramming is associated with cancer development and therapy resistance. Here, the authors show that downregulation of the serine biosynthesis enzyme PHGDH in a fraction of patients is associated with relapse in platinum-treated ovarian

Externí odkaz: https://doaj.org/article/ea6155ed60d848d191feda4d57429fb3

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A heuristic to control integrated multi-product multi-machine production-inventory systems with job shop routings and stochastic arrival, set-up and processing times

Autor: Van Nyen, P. L.M., Bertrand, J. W.M., Van Ooijen, H. P.G., Vandaele, N. J., Liberopulos, G., Papadopoulos, C.T., Tan, B., MacGregor Smith, J., Gershwin, S.B.

Publikováno v: Stochastic Modeling of Manufacturing Systems ISBN: 9783540265795
Stochastic Modeling of Manufacturing Systems: Advances in Design, Performance Evaluation, and Control Issues, 253-288
STARTPAGE=253;ENDPAGE=288;TITLE=Stochastic Modeling of Manufacturing Systems

This paper investigates a multi-product multi-machine production-inventory system, characterized by job shop routings and stochastic demand interarrival times, set-up times and processing times. The inventory points and the production system are cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b53018f799ccd0c5482d64373c00bc6
http://www.scopus.com/inward/record.url?scp=84889998816&partnerID=8YFLogxK

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