Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans.

Autor: Salvadore G; Janssen Research & Development, LLC, Titusville, NJ, USA., Bonaventure P; Janssen Research & Development, LLC, San Diego, CA, USA. pbonave1@its.jnj.com., Shekhar A; Departments of Psychiatry, and Pharmacology, Indiana University, School of Medicine, Indianapolis, IN, USA., Johnson PL; Department of Anatomy, Physiology and Cell Biology, Indiana University, School of Medicine, Indianapolis, IN, USA., Lord B; Janssen Research & Development, LLC, San Diego, CA, USA., Shireman BT; Janssen Research & Development, LLC, San Diego, CA, USA., Lebold TP; Janssen Research & Development, LLC, San Diego, CA, USA., Nepomuceno D; Janssen Research & Development, LLC, San Diego, CA, USA., Dugovic C; Janssen Research & Development, LLC, San Diego, CA, USA., Brooks S; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands., Zuiker R; Centre for Human Drug Research, Leiden, The Netherlands., Bleys C; Janssen Research & Development, LLC, Beerse, Belgium., Tatikola K; Janssen Scientific Affairs, LLC, Titusville, NJ, USA., Remmerie B; Janssen Research & Development, LLC, Beerse, Belgium., Jacobs GE; Centre for Human Drug Research, Leiden, The Netherlands.; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands., Schruers K; Research School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Moyer J; Janssen Research & Development, LLC, Titusville, NJ, USA., Nash A; Janssen Scientific Affairs, LLC, Titusville, NJ, USA., Van Nueten LGM; Janssen Research & Development, LLC, Beerse, Belgium., Drevets WC; Janssen Research & Development, LLC, San Diego, CA, USA.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2020 Sep 07; Vol. 10 (1), pp. 308. Date of Electronic Publication: 2020 Sep 07.