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Autor:
van Nimwegen, Erik
With the number of fully-sequenced genomes now well over a hundred it has become possible to start investigating if there are any quantitative regularities in the genetic make-up of genomes. In (physics/0307001), I originally showed that the numbers
Externí odkaz:
http://arxiv.org/abs/q-bio/0405022
Autor:
van Nimwegen, Erik
With the number of sequenced genomes now over one hundred, and the availability of rough functional annotations for a substantial proportion of their genes, it has become possible to study the statistics of gene content across genomes. Here I show th
Externí odkaz:
http://arxiv.org/abs/physics/0307001
Publikováno v:
PNAS 99 (2002) 7323-7328 (This ArXiv version is slighly modified and contains the "suppporting text" as appendices.)
Genome wide comparisons between enteric bacteria yield large sets of conserved putative regulatory sites on a gene by gene basis that need to be clustered into regulons. Using the assumption that regulatory sites can be represented as samples from we
Externí odkaz:
http://arxiv.org/abs/physics/0206045
We analytically study the dynamics of evolving populations that exhibit metastability on the level of phenotype or fitness. In constant selective environments, such metastable behavior is caused by two qualitatively different mechanisms. One the one
Externí odkaz:
http://arxiv.org/abs/adap-org/9907002
We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population's limit distribution on the neutral network is solely determined by the network topology and given by the p
Externí odkaz:
http://arxiv.org/abs/adap-org/9903006
We analyze the population dynamics of a broad class of fitness functions that exhibit epochal evolution---a dynamical behavior, commonly observed in both natural and artificial evolutionary processes, in which long periods of stasis in an evolving po
Externí odkaz:
http://arxiv.org/abs/adap-org/9903001
Epochal dynamics, in which long periods of stasis in population fitness are punctuated by sudden innovations, is a common behavior in both natural and artificial evolutionary processes. We use a recent quantitative mathematical analysis of epochal ev
Externí odkaz:
http://arxiv.org/abs/adap-org/9810003
Epochal dynamics, in which long periods of stasis in an evolving population are punctuated by a sudden burst of change, is a common behavior in both natural and artificial evolutionary processes. We analyze the population dynamics for a class of fitn
Externí odkaz:
http://arxiv.org/abs/adap-org/9810004