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Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models.

Autor: Teuscher KB; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Chowdhury S; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Meyers KM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Tian J; Molecular Design and Synthesis Center, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232-0142., Sai J; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Van Meveren M; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., South TM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Sensintaffar JL; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Rietz TA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Goswami S; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Wang J; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232-0004.; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232-0004., Grieb BC; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-0011., Lorey SL; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Howard GC; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Liu Q; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232-0004.; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232-0004., Moore WJ; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201., Stott GM; Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21701-4907., Tansey WP; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Lee T; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146., Fesik SW; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.; Department of Chemistry, Vanderbilt University, Nashville, TN 37232-0146.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 03; Vol. 120 (1), pp. e2211297120. Date of Electronic Publication: 2022 Dec 27.