Výsledky vyhledávání - "Van Marrewijk, Laura M"

GPN does not release lysosomal Ca2+ but evokes Ca2+ release from the ER by increasing the cytosolic pH independently of cathepsin C

Autor: Atakpa, Peace, Van Marrewijk, Laura M, Apta-Smith, Michael, Chakraborty, Sumita, Taylor, Colin W

The dipeptide glycyl-l-phenylalanine 2-naphthylamide (GPN) is widely used to perturb lysosomes because its cleavage by the lysosomal enzyme cathepsin C is proposed to rupture lysosomal membranes. We show that GPN evokes a sustained increase in lysoso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4c7be05d2bf5bf880cc4b8818b0d49

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GPN does not release lysosomal Ca²⁺ but evokes Ca²⁺ release from the ER by increasing the cytosolic pH independently of cathepsin C.

Autor: Atakpa, Peace, van Marrewijk, Laura M., Apta-Smith, Michael, Chakraborty, Sumita, Taylor, Colin W.

Publikováno v: Journal of Cell Science; Feb2019, Vol. 132 Issue 3, p1-12, 12p

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Periodical

SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism

Autor: van Marrewijk, Laura M., Polyak, Steven W., Hijnen, Marcel, Kuruvilla, Dana, Chang, Mi Ra, Shin, Youseung, Kamenecka, Theodore M., Griffin, Patrick R., Bruning, John B.

Publikováno v: ACS Chemical Biology; January 2016, Vol. 11 Issue: 1 p273-283, 11p

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SR2067 reveals a unique kinetic and structural signature for PPARγ partial agonism

Autor: John B. Bruning, Mi Ra Chang, Dana S. Kuruvilla, Patrick R. Griffin, Laura M. van Marrewijk, Steven W. Polyak, Youseung Shin, Marcel Hijnen, Theodore M. Kamenecka

Synthetic full agonists of PPARγ have been prescribed for the treatment of diabetes due to their ability to regulate glucose homeostasis and insulin sensitization. While the use of full agonists of PPARγ has been hampered due to severe side effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef1c65a9a684644203b3159b622f1f4
https://hdl.handle.net/11541.2/134089

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GPN does not release lysosomal Ca ²⁺ but evokes Ca ²⁺ release from the ER by increasing the cytosolic pH independently of cathepsin C.

Autor: Atakpa P; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK., van Marrewijk LM; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK., Apta-Smith M; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK., Chakraborty S; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK., Taylor CW; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK cwt1000@cam.ac.uk.

Publikováno v: Journal of cell science [J Cell Sci] 2019 Feb 01; Vol. 132 (3). Date of Electronic Publication: 2019 Feb 01.

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