Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Autor: Bert Dhondt, Gary P. Schroth, Celine Everaert, Avila Cobos F, Jasper Anckaert, Nurten Yigit, Jill Deleu, Eva Hulstaert, Van Maerken T, Vanden Eynde E, Piofczyk T, Scott Kuersten, Annelien Morlion, De Wever O, Anneleen Decock, De Wilde J, Kathleen Schoofs, Pieter Mestdagh, Kimberly Verniers, Thibaut D’huyvetter, An Hendrix, Justine Nuytens, Philippron A, Hetty Helsmoortel, Jo Vandesompele, Van Paemel R, Nele Nijs, Carolina Fierro

The use of blood-based extracellular RNA (cell-free RNA; exRNA) as clinical biomarker requires the implementation of a validated procedure for sample collection, processing, and profiling. So far, no study has systematically addressed the pre-analyti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33c22152e1f08a0a56865339c2c14a4c
https://doi.org/10.1101/2021.05.11.442610

Digital PCR-based evaluation of nucleic acid extraction kit performance for the co-purification of cell-free DNA and RNA.

Autor: Deleu J; OncoRNALab, Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Schoofs K; OncoRNALab, Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Translational Oncogenomics and Bioinformatics Lab, Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Center for Medical Biotechnology, VIB-UGent, Ghent, Belgium., Decock A; OncoRNALab, Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Verniers K; OncoRNALab, Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Roelandt S; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Translational Oncogenomics and Bioinformatics Lab, Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Center for Medical Biotechnology, VIB-UGent, Ghent, Belgium., Denolf A; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Translational Oncogenomics and Bioinformatics Lab, Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Verreth J; OncoRNALab, Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., De Wilde B; OncoRNALab, Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Department of Paediatric Haematology Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium., Van Maerken T; OncoRNALab, Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Department of Laboratory Medicine, AZ Groeninge, Kortrijk, Belgium., De Preter K; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Translational Oncogenomics and Bioinformatics Lab, Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Center for Medical Biotechnology, VIB-UGent, Ghent, Belgium., Vandesompele J; OncoRNALab, Cancer Research Institute Ghent (CRIG), Ghent, Belgium. jo.vandesompele@ugent.be.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium. jo.vandesompele@ugent.be.

Publikováno v: Human genomics [Hum Genomics] 2022 Dec 31; Vol. 16 (1), pp. 73. Date of Electronic Publication: 2022 Dec 31.

Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14^ARF-MDM2-p53 axis.

Autor: Van Maerken, T.^1,2 Tom.VanMaerken@UGent.be, Vandesompele, J.¹, Rihani, A.¹, De Paepe, A.¹, Speleman, F.¹

Publikováno v: Cell Death & Differentiation. Dec2009, Vol. 16 Issue 12, p1563-1572. 10p. 4 Diagrams.

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A G316A Polymorphism in the Ornithine Decarboxylase Gene Promoter Modulates MYCN-Driven Childhood Neuroblastoma.

Autor: Gamble LD; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia., Purgato S; Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy., Henderson MJ; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia., Di Giacomo S; Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy., Russell AJ; Cancer Research Program, The Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia., Pigini P; Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy., Murray J; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia., Valli E; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia., Milazzo G; Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy., Giorgi FM; Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy., Cowley M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia., Ashton LJ; Research Portfolio, University of Sydney, Sydney, NSW 2008, Australia., Bhalshankar J; SIREDO, Department of Paediatric, Adolescents and Young Adults Oncology and INSERM U830, Institut Curie, 26 rue d'Ulm, 75005 Paris, France., Schleiermacher G; SIREDO, Department of Paediatric, Adolescents and Young Adults Oncology and INSERM U830, Institut Curie, 26 rue d'Ulm, 75005 Paris, France., Rihani A; Center for Medical Genetics, Ghent University, C. Heymanslaan 10, 9000 Ghent, Belgium., Van Maerken T; Center for Medical Genetics, Ghent University, C. Heymanslaan 10, 9000 Ghent, Belgium., Vandesompele J; Center for Medical Genetics, Ghent University, C. Heymanslaan 10, 9000 Ghent, Belgium., Speleman F; Center for Medical Genetics, Ghent University, C. Heymanslaan 10, 9000 Ghent, Belgium., Versteeg R; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, 1100 Amsterdam, The Netherlands., Koster J; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, 1100 Amsterdam, The Netherlands., Eggert A; Department of Pediatric Hematology, Oncology and SCT, Charité-University Hospital Berlin, Campus Virchow-Klinikum, 10117 Berlin, Germany., Noguera R; Department of Pathology, Medical School, University of Valencia, 46010 Valencia, Spain.; CIBERONC-INCLIVA, Biomedical Health Research Institute, 46010 Valencia, Spain., Stallings RL; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, D02 YN77 Dublin 2, Ireland., Tonini GP; Neuroblastoma Laboratory, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy., Fong K; Thoracic Research Centre, University of Queensland, The Prince Charles Hospital, Brisbane, QLD 4032, Australia., Vaksman Z; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Diskin SJ; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Maris JM; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., London WB; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA 02215, USA., Marshall GM; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; Kids Cancer Centre, Sydney Children's Hospital, High St, Randwick, NSW 2031, Australia., Ziegler DS; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; Kids Cancer Centre, Sydney Children's Hospital, High St, Randwick, NSW 2031, Australia., Hogarty MD; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Perini G; Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy., Norris MD; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; Centre for Childhood Cancer Research, University of New South Wales, Sydney, NSW 2052, Australia., Haber M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.

Publikováno v: Cancers [Cancers (Basel)] 2021 Apr 09; Vol. 13 (8). Date of Electronic Publication: 2021 Apr 09.