Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Van M. Hoang"'
Autor:
Zhifeng Chen, Lan Zhang, Aimin Tang, Cheryl Callahan, Pavlo Pristatsky, Ryan Swoyer, Pedro Cejas, Debbie Nahas, Jennifer Galli, Scott Cosmi, Daniel DiStefano, Van M Hoang, Andrew Bett, Danilo Casimiro, Kalpit A Vora
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156798 (2016)
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection in infants, the elderly and in immunosuppressed populations. The vast majority of neutralizing antibodies isolated from human subjects target the RSV fusion (F)
Externí odkaz:
https://doaj.org/article/73155741d0404b628aaa41985e4d1d0a
Autor:
Colleen E. Price, Sha Ha, John W. Loughney, Van M. Hoang, Catherine Lancaster, Richard R. Rustandi
Publikováno v:
Journal of Chromatography A. 1498:169-175
Clostridium difficile infection (CDI) is the leading cause of gastroenteritis-associated death in the United States. The major virulent factors of C. difficile are toxin A (TcdA) and toxin B (TcdB). Toxicity is mediated by the glucosyltransferase dom
Characterization of N -glycosylation profiles from mammalian and insect cell derived chikungunya VLP
Autor:
Richard M. Schwartz, Catherine Lancaster, Richard R. Rustandi, Sha Ha, Danilo R. Casimiro, Van M. Hoang, Pavlo Pristatsky
Publikováno v:
Journal of Chromatography B. 1032:218-223
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes severe arthralgia. The envelope of CHIKV is composed of 240 copies of two glycoproteins: E1 and E2. In this work, we have characterized the N-glycosylation patterns of CHIKV virus-l
Publikováno v:
Journal of the American Society for Mass Spectrometry. 30(3)
Direct characterization of disulfide linkages in proteins by mass spectrometry has been challenging. Here, we report analysis of disulfide linkages in insulin variant, endothelin 3, and relaxin 2 by in-source dissociation (ISD) during LC-MS. A duplet
Autor:
Pete A. DePhillips, Dai Wang, Colleen E. Price, Matthew C. Troutman, Daniel C. Freed, Lawrence W. Dick, Timothy D. Culp, Guanghua Li, Van M. Hoang, Zhong Liu, Tong-Ming Fu, Sha Ha, John W. Loughney, Richard R. Rustandi, Fengsheng Li
Publikováno v:
Journal of Biological Chemistry. 290:15985-15995
Congenital infection of human cytomegalovirus (HCMV) is one of the leading causes of nongenetic birth defects, and development of a prophylactic vaccine against HCMV is of high priority for public health. The gH/gL/pUL128–131 pentameric complex med
Autor:
Craig T. Przysiecki, Lawrence W. Dick, Lan Zhang, Sha Ha, John T. Mehl, John W. Loughney, Van M. Hoang, Lance Dieter, Richard R. Rustandi, Anna Mach
Publikováno v:
Human Vaccines & Immunotherapeutics. 11:1518-1525
The development of a multivalent outer membrane vesicle (OMV) vaccine where each strain contributes multiple key protein antigens presents numerous analytical challenges. One major difficulty is the ability to accurately and specifically quantitate e
Autor:
Pavlo Pristatsky, Sha Ha, Anastasia Shytuhina, Danilo R. Casimiro, Jian He, Richard M. Schwartz, Van M. Hoang
Publikováno v:
Journal of Chromatography A. 1364:192-197
To effectively support the development of a Chikungunya (CHIKV) virus-like particle (VLP) vaccine, a sensitive and robust high-performance liquid chromatography (HPLC) method that can quantitate CHIKV VLPs and monitor product purity throughout the ma
Autor:
Van M. Hoang, Tosha Shah, Tim Culp, Belma Dogdas, Christopher J. Farrell, Harrison Davis, Stephanie M. Cicalese
The productivity of cell culture-derived vaccines grown in anchorage-dependent animal cells is limited by bioreactor surface area. One way to increase the available surface area is by growing cells as monolayers on small spheres called microcarriers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529caebb90a3bf659ce60b5697c7bf0a
https://europepmc.org/articles/PMC5101317/
https://europepmc.org/articles/PMC5101317/
Publikováno v:
Vaccine. 34(20)
Despite a 40-year effort, an effective vaccine against human cytomegalovirus (HCMV) remains an unmet medical need. The discovery of potent neutralizing epitopes on the pentameric gH complex (gH/gL/UL128/130/131) has reenergized HCMV vaccine developme
Autor:
Karl R. Clauser, Van M. Hoang, Alma L. Burlingame, Bradford W. Gibson, Susan J. Fisher, Russell A. Foulk
Publikováno v:
Biochemistry. 40:4077-4086
The outcome of human pregnancy depends on the differentiation of cytotrophoblasts, specialized placental cells that physically connect the embryo/fetus to the mother. As cytotrophoblasts differentiate, they acquire tumor-like characteristics that ena