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of 41
pro vyhledávání: '"Van Liefde, Isabelle"'
Publikováno v:
In Drug Discovery Today: Technologies October 2015 17:28-34
Publikováno v:
British Journal of Pharmacology. Apr2016, Vol. 173 Issue 8, p1268-1285. 18p. 1 Diagram, 5 Charts, 5 Graphs.
Bivalent ligands bear two target-binding pharmacophores. Their simultaneous binding increases their affinity (avidity) and residence time. They become "bitopic" when the pharmacophores exert allosteric modulation of each other's affinity and/or activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::e363ec15349aee78e14e37286f90b1ca
https://biblio.vub.ac.be/vubir/avidity-and-positive-allosteric-modulationcooperativity-act-hand-in-hand-to-increase-the-residence-time-of-bivalent-receptor-ligands-doi-101111fcp12052(11876401-8fe5-411c-b223-cc56672ae38e).html
https://biblio.vub.ac.be/vubir/avidity-and-positive-allosteric-modulationcooperativity-act-hand-in-hand-to-increase-the-residence-time-of-bivalent-receptor-ligands-doi-101111fcp12052(11876401-8fe5-411c-b223-cc56672ae38e).html
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The ability of antagonists to form slow-dissociating complexes with their cognate receptor has been repeatedly proposed to contribute to their long- lasting clinical action. Yet, specific conditions appear to be necessary for this to take place. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::60c6fb302d7acdae3815035739649967
https://biblio.vub.ac.be/vubir/from-slow-antagonist-dissociation-to-long-lasting-receptor-protection(633600fb-9b95-41da-b6df-e409287c0186).html
https://biblio.vub.ac.be/vubir/from-slow-antagonist-dissociation-to-long-lasting-receptor-protection(633600fb-9b95-41da-b6df-e409287c0186).html
The ability of biphenyltetrazole AT1 receptor antagonists (BTsartans) to block angiotensin II (Ang II)- mediated responses has been extensively investigated in vascular tissues and, more recently, in Chinese Hamster Ovary cells expressing the human A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::79d68fc8ed784a5ca17afafd8ce7db9f
https://biblio.vub.ac.be/vubir/longlasting-at1-receptor-binding-and-protection-by-candesartan-comparison-to-other-biphenyltetrazole-sartans(5718d2d8-ed29-42cb-b8fb-ace1a0c08ea2).html
https://biblio.vub.ac.be/vubir/longlasting-at1-receptor-binding-and-protection-by-candesartan-comparison-to-other-biphenyltetrazole-sartans(5718d2d8-ed29-42cb-b8fb-ace1a0c08ea2).html
G protein- coupled receptors (GPCRs) were initially regarded to adopt an inactive and an active conformation and to activate a single type of G protein. Studies with recombinant cell systems have led to a more complex picture. First, GPCRs can activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::1f84bea66f062c8f9ea7458afd97bcdf
https://biblio.vub.ac.be/vubir/g-protein-coupled-receptors-a-count-of-1001-conformations(4e366176-9456-4a63-8838-28c6c88770c3).html
https://biblio.vub.ac.be/vubir/g-protein-coupled-receptors-a-count-of-1001-conformations(4e366176-9456-4a63-8838-28c6c88770c3).html
Akademický článek
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