Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis.

Autor: Nüesch E; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.; CTU Bern, Department of Clinical Research and Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland., Dale C; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK., Palmer TM; Warwick Medical School, University of Warwick, Coventry, UK.; Department of Mathematics and Statistics, Lancaster University, Lancaster, UK., White J; UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, London, UK., Keating BJ; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Surgery.; Division of Genetics, University of Pennsylvania, Philadelphia., van Iperen EP; Department of Biostatistics, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands., Goel A; Wellcome Trust Centre for Human Genetics and Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Asselbergs FW; Department of Cardiology, Division Heart and Lungs, University Medical Centre Utrecht, Utrecht, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK., Verschuren WM, Wijmenga C, Van der Schouw YT, Onland-Moret NC; EPIC-NL, Bilthoven and Utrecht, The Netherlands., Lange LA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hovingh GK; Department of Vascular Medicine, Academic Medical Center Amsterdam, Amsterdam, The Netherlands., Sivapalaratnam S; Department of Vascular Medicine, Academic Medical Center Amsterdam, Amsterdam, The Netherlands., Morris RW; Department of Primary Care & Population Health, University College London, London, UK., Whincup PH; Population Health Research Institute, St George's, University of London, London, UK., Wannamethe GS; Department of Primary Care & Population Health, University College London, London, UK., Gaunt TR; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., Ebrahim S; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK., Steel L; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Nair N; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA / Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Wilson JF; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Bolton JL; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., McLachlan S; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Price JF; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Strachan MW; Metabolic Unit, Western General Hospital, Edinburgh, UK., Robertson CM; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Kleber ME; Fifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., Delgado G; Fifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., März W; Medical Clinic V (Nephrology, Hypertensiology, Endocrinology, Diabetolgy, and Rheumatology), Mannheim Medical Faculty, University of Heidelberg, Germany, Synlab Academy, Synlab Services GmbH, Mannheim and Augsburg, Germany, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria., Melander O; Lund University, Sweden., Dominiczak AF; Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Farrall M; Wellcome Trust Centre for Human Genetics and Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Watkins H; Wellcome Trust Centre for Human Genetics and Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Leusink M; Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Maitland-van der Zee AH; Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., de Groot MC; Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Dudbridge F; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK., Hingorani A; Department of Epidemiology and Public Health, University College London Medical School, London, UK., Ben-Shlomo Y; School of Social and Community Medicine, University of Bristol, Bristol, UK., Lawlor DA; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., Amuzu A, Caufield M, Cavadino A, Cooper J, Davies TL, Drenos F, Engmann J, Finan C, Giambartolomei C, Hardy R, Humphries SE, Hypponen E, Kivimaki M, Kuh D, Kumari M, Ong K, Plagnol V, Power C, Richards M, Shah S, Shah T, Sofat R, Talmud PJ, Wareham N, Warren H, Whittaker JC, Wong A, Zabaneh D; UCLEB, London, Edinburgh and Bristol, UK., Davey Smith G; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., Wells JC; Childhood Nutrition Research Centre, UCL Institute of Child Health, London, UK., Leon DA; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.; Department of Community Medicine, Arctic University of Norway, UiT., Holmes MV; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.; Department of Surgery and Clinical Epidemiology Unit, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK., Casas JP; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.

Publikováno v: International journal of epidemiology [Int J Epidemiol] 2016 Dec 01; Vol. 45 (6), pp. 1927-1937.

A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering.

Autor: Leusink M; Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.; Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Maitland-van der Zee AH; Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Ding B; Medical Evidence & Observational Research Center, Global Medical Affairs, AstraZeneca R&D Gothenburg, Mölndal, Sweden., Drenos F; Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., van Iperen EP; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.; Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Academic Medical Center Amsterdam, Amsterdam, The Netherlands., Warren HR; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; The National Heart, Lung, & Blood Institute Framingham Heart Study, Framingham, MA, USA., Cushman M; Departments of Medicine & Pathology, University of Vermont, Burlington, VT, USA., Hingorani AD; Department of Epidemiology & Public Health, UCL Institute of Epidemiology & Health Care, University College London, London, UK., Hoogeveen RC; Division of Atherosclerosis & Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Hovingh GK; Department of Vascular Medicine, Academic Medical Center Amsterdam, Amsterdam, The Netherlands., Kumari M; Department of Epidemiology & Public Health, UCL Institute of Epidemiology & Health Care, University College London, London, UK., Lange LA; Department of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, NC, USA., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK., Nyberg F; Medical Evidence & Observational Research Center, Global Medical Affairs, AstraZeneca R&D Gothenburg, Mölndal, Sweden.; Occupational & Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Schreiner PJ; School of Public Health, University of Minnesota, Minneapolis, MN, USA., Sivapalaratnam S; Department of Vascular Medicine, Academic Medical Center Amsterdam, Amsterdam, The Netherlands., de Bakker PI; Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands., de Boer A; Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Keating BJ; Division of Transplantation, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA., Asselbergs FW; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.; Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.; Faculty of Population Health Sciences, Institute of Cardiovascular Science, University College London, London, UK., Onland-Moret NC; Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

Publikováno v: Pharmacogenomics [Pharmacogenomics] 2016 Apr; Vol. 17 (6), pp. 583-91. Date of Electronic Publication: 2016 Apr 05.

HBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels.

Autor: Jansen L; Department of Gastroenterology and Hepatology, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands; Department of Experimental Immunology, AMC, UvA, The Netherlands., de Niet A; Department of Gastroenterology and Hepatology, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands; Department of Experimental Immunology, AMC, UvA, The Netherlands., Stelma F; Department of Gastroenterology and Hepatology, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands; Department of Experimental Immunology, AMC, UvA, The Netherlands., van Iperen EP; Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, AMC, UvA, The Netherlands; Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands., van Dort KA; Department of Experimental Immunology, AMC, UvA, The Netherlands., Plat-Sinnige MJ; Department of Gastroenterology and Hepatology, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands; Department of Experimental Immunology, AMC, UvA, The Netherlands., Takkenberg RB; Department of Gastroenterology and Hepatology, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands., Chin DJ; Hoffman La Roche, Nutley, USA., Zwinderman AH; Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, AMC, UvA, The Netherlands., Lopatin U; Assembly Pharmaceuticals, Bloomington, IN, USA., Kootstra NA; Department of Experimental Immunology, AMC, UvA, The Netherlands., Reesink HW; Department of Gastroenterology and Hepatology, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands. Electronic address: h.w.reesink@amc.nl.

Publikováno v: Journal of hepatology [J Hepatol] 2014 Oct; Vol. 61 (4), pp. 730-7. Date of Electronic Publication: 2014 May 10.

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.

Autor: Tragante V; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands., Barnes MR; William Harvey Research Institute National Institute for Health Biomedical Research Unit, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK., Ganesh SK; Division of Cardiovascular Medicine, Departments of Internal Medicine and Human Genetics, University of Michigan Health System, Ann Arbor, MI 48109, USA., Lanktree MB; Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada., Guo W; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA., Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA., Smith EN; Department of Pediatrics and Rady's Children's Hospital, University of California at San Diego, School of Medicine, La Jolla, CA 92093, USA., Johnson T; Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Holmes MV; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Padmanabhan S; BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, UK., Karczewski KJ; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Almoguera B; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Barnard J; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA., Baumert J; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany., Chang YP; Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Elbers CC; Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands., Farrall M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Fischer ME; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA., Gaunt TR; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., Gho JM; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany., Goel A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Gong Y; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3015 GE Rotterdam, the Netherlands., Kleber ME; Medical Clinic V, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany., Mateo Leach I; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., McDonough CW; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA., Meijs MF; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands., Melander O; Hypertension and Cardiovascular Disease, Department of Clinical Sciences, Lund University, Malmö 20502, Sweden; Centre of Emergency Medicine, Skåne University Hospital, Malmö 20502, Sweden., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Pankratz N; Institute of Human Genetics, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA., Price TS; MRC SGDP Centre, Institute of Psychiatry, London SE5 8AF, UK., Shaffer J; Department of Medicine, Columbia University, New York, NY 10032, USA., Shah S; UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, Kathleen Lonsdale Building, Gower Place, London WC1E 6BT, UK., Tomaszewski M; Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Van Iperen EP; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands., Vonk JM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Witkowska K; Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Wong CO; Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Zhang L; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA., Beitelshees AL; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Berenson GS; Department of Epidemiology, Tulane University, New Orleans, LA 70118, USA., Bhatt DL; Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Brown M; Clinical Pharmacology Unit, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK., Burt A; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA 98195, USA., Cooper-DeHoff RM; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA., Connell JM; University of Dundee, Ninewells Hospital &Medical School, Dundee DD1 9SY, UK., Cruickshanks KJ; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA; Department of Population Health Sciences, University of Wisconsin, Madison, WI 53726, USA., Curtis SP; Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA., Davey-Smith G; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., Delles C; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK., Gansevoort RT; Division of Nephrology, Department of Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Guo X; Cedars-Sinai Med Ctr-PEDS, Los Angeles, CA 90048, USA., Haiqing S; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Hastie CE; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK., Hofker MH; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Department Pathology and Medical Biology, Medical Biology Division, Molecular Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Hovingh GK; Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands., Kim DS; Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Seattle, WA 98195, USA., Kirkland SA; Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS B3H 1V7, Canada., Klein BE; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA., Klein R; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA., Li YR; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Maiwald S; Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands., Newton-Cheh C; Broad Institute of Harvard and MIT, Massachusetts General Hospital, Boston, MA 02142, USA., O'Brien ET; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland., Onland-Moret NC; Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands., Palmas W; Department of Medicine, Columbia University, New York, NY 10032, USA., Parsa A; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Penninx BW; Department of Psychiatry/EMGO Institute, VU University Medical Centre, 1081 BT Amsterdam, the Netherlands., Pettinger M; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Vasan RS; Department of Medicine, Boston University School of Medicine, Framingham, MA 02118, USA., Ranchalis JE; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA 98195, USA., M Ridker P; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Sever P; International Centre for Circulatory Health, Imperial College London, W2 1LA UK., Shimbo D; Department of Medicine, Columbia University, New York, NY 10032, USA., Steele L; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Stolk RP; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Thorand B; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany., Trip MD; Department of Cardiology, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3015 GE Rotterdam, the Netherlands., Verschuren WM; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, the Netherlands., Wijmenga C; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Wyatt S; Schools of Nursing and Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA., Young JH; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Zwinderman AH; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands., Bezzina CR; Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands; Molecular and Experimental Cardiology Group, Academic Medical Centre, 1105 AZ Amsterdam, the Netherlands., Boerwinkle E; Human Genetics Center and Institute of Molecular Medicine and Division of Epidemiology, University of Texas Health Science Center, Houston, TX 77030, USA., Casas JP; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK; Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Caulfield MJ; Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Chakravarti A; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA., Davidson KW; Departments of Medicine & Psychiatry, Columbia University, New York, NY 10032, USA., Doevendans PA; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands., Dominiczak AF; BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, UK., FitzGerald GA; The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Gums JG; Departments of Pharmacotherapy and Translational Research and Community Health and Family Medicine, University of Florida, Gainesville, FL 32610, USA., Fornage M; Institute of Molecular Medicine and School of Public Health Division of Epidemiology Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Hakonarson H; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Halder I; School of Medicine, University of Pittsburgh, PA 15261, USA., Hillege HL; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Illig T; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany., Jarvik GP; International Centre for Circulatory Health, Imperial College London, W2 1LA UK., Johnson JA; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA., Kastelein JJ; Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands., Koenig W; Department of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm 89081, Germany., Kumari M; Department of Epidemiology and Public Health, Division of Population Health, University College London, Torrington Place, London WC1E 7HB, UK., März W; Medical Clinic V, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany; Synlab Academy, Synlab Services GmbH, Mannheim 69214, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria., Murray SS; Department of Pathology, University of California San Diego, La Jolla, CA 92037, USA., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Pankow JS; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA., Rader DJ; Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Redline S; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA., Reilly MP; Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Schadt EE; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA., Kottke-Marchant K; Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Snyder M; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Stanton AV; Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland., Tobin MD; Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK., Uitterlinden AG; Departments of Epidemiology and Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, the Netherlands., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., van der Schouw YT; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK., Watkins H; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Johnson AD; National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA 01702, USA., Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Zhu X; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA., de Bakker PI; Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA and Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Levy D; Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA., Asselbergs FW; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London WC1E 6BT, UK., Munroe PB; Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. Electronic address: p.b.munroe@qmul.ac.uk., Keating BJ; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: bkeating@mail.med.upenn.edu.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2014 Mar 06; Vol. 94 (3), pp. 349-60. Date of Electronic Publication: 2014 Feb 20.

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

Autor: Ganesh SK; Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, MI, USA., Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Franceschini N, Gaunt TR, Gho JM, Gieger C, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MF, Mellander O, Molony CM, Nolte IM, Padmanabhan S, Price TS, Rajagopalan R, Shaffer J, Shah S, Shen H, Soranzo N, van der Most PJ, Van Iperen EP, Van Setten J, Vonk JM, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Boer JM, Boerwinkle E, Burkley B, Burt A, Chakravarti A, Chen W, Cooper-Dehoff RM, Curtis SP, Dreisbach A, Duggan D, Ehret GB, Fabsitz RR, Fornage M, Fox E, Furlong CE, Gansevoort RT, Hofker MH, Hovingh GK, Kirkland SA, Kottke-Marchant K, Kutlar A, Lacroix AZ, Langaee TY, Li YR, Lin H, Liu K, Maiwald S, Malik R, Murugesan G, Newton-Cheh C, O'Connell JR, Onland-Moret NC, Ouwehand WH, Palmas W, Penninx BW, Pepine CJ, Pettinger M, Polak JF, Ramachandran VS, Ranchalis J, Redline S, Ridker PM, Rose LM, Scharnag H, Schork NJ, Shimbo D, Shuldiner AR, Srinivasan SR, Stolk RP, Taylor HA, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Winkelmann BR, Wyatt S, Young JH, Boehm BO, Caulfield MJ, Chasman DI, Davidson KW, Doevendans PA, Fitzgerald GA, Gums JG, Hakonarson H, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJ, Koenig W, März W, Mitchell BD, Murray SS, Oldehinkel AJ, Rader DJ, Reilly MP, Reiner AP, Schadt EE, Silverstein RL, Snieder H, Stanton AV, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Johnson AD, Munroe PB, de Bakker PI, Zhu X, Levy D, Keating BJ, Asselbergs FW

Publikováno v: Human molecular genetics [Hum Mol Genet] 2013 Apr 15; Vol. 22 (8), pp. 1663-78. Date of Electronic Publication: 2013 Jan 08.