Zobrazeno 1 - 10
of 548
pro vyhledávání: '"Van Hummelen P"'
Publikováno v:
BMC Bioinformatics, Vol 10, Iss 1, p 3 (2009)
Abstract Background Affymetrix Genechips are characterized by probe pairs, a perfect match (PM) and a mismatch (MM) probe differing by a single nucleotide. Most of the data preprocessing algorithms neglect MM signals, as it was shown that MMs cannot
Externí odkaz:
https://doaj.org/article/6199382634a644fb877fa72f81a7e64a
Publikováno v:
Nucleic Acid Research 37, e53 (2009)
Quantifying interactions in DNA microarrays is of central importance for a better understanding of their functioning. Hybridization thermodynamics for nucleic acid strands in aqueous solution can be described by the so-called nearest-neighbor model,
Externí odkaz:
http://arxiv.org/abs/1001.0653
Publikováno v:
J. Phys. Chem. B 111, 13583 (2007)
While designing oligonucleotide-based microarrays, cross-hybridization between surface-bound oligos and non-intended labeled targets is probably the most difficult parameter to predict. Although literature describes rules-of-thumb concerning oligo le
Externí odkaz:
http://arxiv.org/abs/0711.2525
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0242218 (2020)
Improvements in survival rates with gonad-sparing protocols for childhood and adolescence cancer have increased the optimism of survivors to become parents after treatment. Findings in rodents indicate that chromosomal aberrations can be induced in m
Externí odkaz:
https://doaj.org/article/cc5708a860284f2c880c6976d7ac63af
Autor:
Wenya Linda Bi, Noah F. Greenwald, Malak Abedalthagafi, Jeremiah Wala, Will J. Gibson, Pankaj K. Agarwalla, Peleg Horowitz, Steven E. Schumacher, Ekaterina Esaulova, Yu Mei, Aaron Chevalier, Matthew A. Ducar, Aaron R. Thorner, Paul van Hummelen, Anat O. Stemmer-Rachamimov, Maksym Artyomov, Ossama Al-Mefty, Gavin P. Dunn, Sandro Santagata, Ian F. Dunn, Rameen Beroukhim
Publikováno v:
npj Genomic Medicine, Vol 2, Iss 1, Pp 1-14 (2017)
Brain tumors: uncovering genomic disruption in meningiomas Meningiomas, which arise from the tissue surrounding the brain and spinal cord, are the most common primary brain tumor in adults. The majority of these are slow-growing and amenable to surgi
Externí odkaz:
https://doaj.org/article/30b733f570624d2fb8c0cba27d4db819
Autor:
Andrew L. Hong, Yuen-Yi Tseng, Glenn S. Cowley, Oliver Jonas, Jaime H. Cheah, Bryan D. Kynnap, Mihir B. Doshi, Coyin Oh, Stephanie C. Meyer, Alanna J. Church, Shubhroz Gill, Craig M. Bielski, Paula Keskula, Alma Imamovic, Sara Howell, Gregory V. Kryukov, Paul A. Clemons, Aviad Tsherniak, Francisca Vazquez, Brian D. Crompton, Alykhan F. Shamji, Carlos Rodriguez-Galindo, Katherine A. Janeway, Charles W. M. Roberts, Kimberly Stegmaier, Paul van Hummelen, Michael J. Cima, Robert S. Langer, Levi A. Garraway, Stuart L. Schreiber, David E. Root, William C. Hahn, Jesse S. Boehm
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomi
Externí odkaz:
https://doaj.org/article/a374f09a5d1640b381b40c1ebaec01db
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Publikováno v:
BioTechniques, Vol 41, Iss 5, Pp 609-616 (2006)
Doughnut shaped hybridization patterns on DNA microarrays are mainly allocated to spotting or drying artifacts. The present study reports on results obtained from four different approaches that when combined generate a better view on the occurrence o
Externí odkaz:
https://doaj.org/article/3a373a9117f14fc8a7824cab75c6e0eb