Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression.

Autor: Kaiser CE; College of Pharmacy, University of Arizona , Tucson, Arizona 85721, United States., Van Ert NA; College of Pharmacy, University of Arizona , Tucson, Arizona 85721, United States., Agrawal P; College of Pharmacy, University of Arizona , Tucson, Arizona 85721, United States., Chawla R; BIO5 Institute, University of Arizona , Tucson, Arizona 85721, United States., Yang D; College of Pharmacy, University of Arizona , Tucson, Arizona 85721, United States.; University of Arizona Cancer Center, University of Arizona , Tucson, Arizona 85724, United States.; BIO5 Institute, University of Arizona , Tucson, Arizona 85721, United States., Hurley LH; College of Pharmacy, University of Arizona , Tucson, Arizona 85721, United States.; University of Arizona Cancer Center, University of Arizona , Tucson, Arizona 85724, United States.; BIO5 Institute, University of Arizona , Tucson, Arizona 85721, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2017 Jun 28; Vol. 139 (25), pp. 8522-8536. Date of Electronic Publication: 2017 Jun 15.