Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A

Autor: van der Plaat, DA, de Jong, K, Lahousse, L, Faiz, A, Vonk, JM, van Diemen, CC, Nedeljkovic, I, Amin, N, Brusselle, GG, Hofman, A, Brandsma, C-A, Bossé, Y, Sin, DD, Nickle, DC, van Duijn, CM, Postma, DS, Boezen, HM

BACKGROUND: Although a striking proportion (25% to 45%) of patients with chronic obstructive pulmonary disease are never-smokers, most genetic susceptibility studies have not focused on this group exclusively. OBJECTIVE: The aim of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::a1d92e46b874f12e52f4a655f5c1b296
https://hdl.handle.net/10453/160198

Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study

Autor: Dijkstra, Akkelies E., Smolonska, J, Van Den Berge, M, Wijmenga, C, Zanen, P, Luinge, MA, Platteel, M, Lammers, JW, Dahlback, M, Tosh, K, Hiemstra, PS, Sterk, PJ, Spira, A, Vestbo, J, Nordestgaard, BG, Benn, M, Nielsen, SF, Dahl, M, Verschuren, WM, Picavet, HSJ, Smit, HA, Owsijewitsch, M, Kauczor, HU, De Koning, HJ, Nizankowska-Mogilnicka, E, Mejza, F, Nastalek, P, Van Diemen, CC, Cho, MH, Silverman, EK, Crapo, JD, Beaty, TH, Lomas, DA, Bakke, Per, Gulsvik, Amund, Bosse, Y, Obeidat, MA, Loth, DW, Lahousse, L, Rivadeneira, F, Uitterlinden, AG, Hofman, A, Stricker, BH, Brusselle, GG, Van Duijn, CM, Brouwer, U, Koppelman, GH, Vonk, JM, Nawijn, MC, Groen, HJM, Timens, W, Boezen, HM, Postma, DS, Alizadeh, BZ, De Boer, RA, Bruinenberg, M, Franke, L, Van Der Harst, P, Hillege, HL, Van Der Klauw, MM, Navis, G, Ormel, J, Rosmalen, J, Slaets, JP, Snieder, H, Stolk, RP, Wolffenbuttel, B

Publikováno v: PLoS ONE
Dijkstra, A E, Smolonska, J, van den Berge, M, Wijmenga, C, Zanen, P, Luinge, M A, Platteel, M, Lammers, J W, Dahlback, M, Tosh, K, Hiemstra, P S, Sterk, P J, Spira, A, Vestbo, J, Nordestgaard, B G, Benn, M, Nielsen, S F, Dahl, M, Verschuren, W M, Picavet, H S J, Smit, H A, Owsijewitsch, M, Kauczor, H U, de Koning, H J, Nizankowska-Mogilnicka, E, Mejza, F, Nastalek, P, van Diemen, C C, Cho, M H, Silverman, E K, Crapo, J D, Beaty, T H, Lomas, D A, Bakke, P, Gulsvik, A, Bosse, Y, Obeidat, M A, Loth, D W, Lahousse, L, Rivadeneira, F, Uitterlinden, A G, Hofman, A, Stricker, B H, Brusselle, G G, van Duijn, C, Brouwer, U, Koppelman, G H, Vonk, J M, Nawijn, M C, Groen, H J M, Timens, W, Boezen, H M, Postma, D S & LifeLines Cohort, S 2014, ' Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study ', P L o S One, vol. 9, no. 4, e91621, pp. 13 . https://doi.org/10.1371/journal.pone.0091621
LifeLines Cohort Study 2014, ' Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study ', PLoS ONE, vol. 9, no. 4, e91621 . https://doi.org/10.1371/journal.pone.0091621
e91621
PLoS ONE, 9(4). Public Library of Science
PLoS One (print), 9(4). Public Library of Science
PLoS ONE, Vol 9, Iss 4, p e91621 (2014)
PLoS ONE, 9(4)
PLOS ONE
PLoS ONE, 9(4):e91621. PUBLIC LIBRARY SCIENCE
PLoS ONE; Vol 9

Background: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. It is associated with smoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74529ee25996a8245709890a3470ca4
https://pubmed.ncbi.nlm.nih.gov/26024482

Restricted IgA repertoire in both B-1 and B-2 cell-derived gut plasmablasts

Autor: Stoel, M, Jiang, HQ, van Diemen, CC, Bun, JCAM, Dammers, PM, Thurnheer, MC, Kroese, FGM, Cebra, JJ, Bos, NA

Publikováno v: Journal of Immunology, 174(2), 1046-1054. AMER ASSOC IMMUNOLOGISTS

Mucosal IgA is the most abundantly produced Ig upon colonization of the intestinal tract with commensal organisms in the majority of mammals. The repertoire of these IgA molecules is still largely unknown; a large amount of the mucosal IgA cannot be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::2295c7ec8c48314c4f8dcac1a9daf9e8
https://research.rug.nl/en/publications/018cf77b-fadf-4638-a8c7-89124baf9618

Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.

Autor: Koppelman GH, Meyers DA, Howard TD, Zheng SL, Hawkins GA, Ampleford EJ, Xu J, Koning H, Bruinenberg M, Nolte IM, van Diemen CC, Boezen HM, Timens W, Whittaker PA, Stine OC, Barton SJ, Holloway JW, Holgate ST, Graves PE, Martinez FD

Publikováno v: American Journal of Respiratory & Critical Care Medicine; Nov2009, Vol. 180 Issue 10, p929-935, 7p

Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants

Autor: Romanos, J., Rosén, A., Kumar, V., Trynka, G., Franke, L., Szperl, A., Gutierrez-Achury, J., van Diemen, C.C., Kanninga, R., Jankipersadsing, S.A., Steck, A., Eisenbarth, G., van Heel, D.A., Cukrowska, B., Bruno, V., Mazzilli, M.C., Núñez, C., Bilbao, J.R., Mearin, M.L., Barisani, D., Rewers, M., Norris, J.M., Ivarsson, A., Boezen. H.M., Liu, E., Wijmenga, C., Prevent, C.D., Kolaček, Sanja, Steck, A, Mearin, M, L, Barisani, D, Rewers, M, Boezen, H.M.

Publikováno v: Gut
Gut, 63(3), 415-422
Europe PubMed Central
Gut, 63(3), 415-422. BMJ PUBLISHING GROUP

Background The majority of coeliac disease (CD) patients are not being properly diagnosed and therefore remain untreated, leading to a greater risk of developing CD-associated complications. The major genetic risk heterodimer, HLA-DQ2 and DQ8, is alr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa93d686d1063caf4cd90e068246773
https://pubmed.ncbi.nlm.nih.gov/23704318